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Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-β signalling
http://hdl.handle.net/2241/114268
http://hdl.handle.net/2241/11426855ccf387-ed03-4d77-a43c-49d76b81ef09
名前 / ファイル | ライセンス | アクション |
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BL_7-5.pdf (626.7 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2011-10-19 | |||||
タイトル | ||||||
タイトル | Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-β signalling | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kurita, Yoshihisa
× Kurita, Yoshihisa× Wada, Hiroshi |
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著者別名 |
和田, 洋
× 和田, 洋 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Gastropods are characterized by their asymmetric bodyplan, which develops through a unique ontogenetic process called ‘torsion’. Despite several intensive studies, the driving force of torsion remains to be determined. Although torsion was traditionally believed to be driven by contraction of the retractor muscle connecting the foot and the shell, some recent reports cast doubt on that idea. Here, we report that torsion is accompanied by left–right asymmetric cell proliferation in the mantle epithelium in the limpet Nipponacmea fuscoviridis. Furthermore, we found that pharmacological inhibition of the transforming growth factor-β (TGF-β) signalling pathway, including that of Nodal, blocked torsion. We confirmed that the blocking was brought about through failure of the activation of cell proliferation in the right-hand side of the mantle epithelium, while the retractor muscle apparently developed normally. These results suggest that limpet torsion is driven by left–right asymmetric cell proliferation in the mantle epithelium, induced by the TGF-β pathway. | |||||
書誌情報 |
Biology letters 巻 7, 号 5, p. 759-762, 発行日 2011-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1744-9561 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1202972X | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 21525052 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1098/rsbl.2011.0263 | |||||
権利 | ||||||
権利情報 | © The Royal Society 2011 | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | The Royal Society | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/114268 | |||||
識別子タイプ | HDL |