{"_buckets": {"deposit": "5931c969-729a-46a3-9308-f90982144773"}, "_deposit": {"id": "20230", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20230"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00020230"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "1109", "bibliographicPageStart": "1100", "bibliographicVolumeNumber": "344", "bibliographic_titles": [{"bibliographic_title": "Developmental biology"}]}]}, "item_5_creator_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u9577\u8c37\u5ddd, \u6f64"}], "nameIdentifiers": [{"nameIdentifier": "71268", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u91d1\u4fdd, \u5b89\u5247"}], "nameIdentifiers": [{"nameIdentifier": "451", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00214437", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000000214437"}, {"nameIdentifier": "0000001622", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001622"}]}, {"creatorNames": [{"creatorName": "\u4e39\u7fbd, \u9686\u4ecb"}], "nameIdentifiers": [{"nameIdentifier": "199", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60507945", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000060507945"}, {"nameIdentifier": "0000001425", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001425"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Developmental timing in the nematode  Caenorhabditis elegans is controlled by heterochronic genes, mutations in which cause changes in the relative timing of developmental events. One of the heterochronic genes, let-7, encodes a microRNA that is highly evolutionarily conserved, suggesting that similar genetic pathways control developmental timing across phyla. Here we report that the nuclear receptor nhr-25, which belongs to the evolutionarily conserved fushi tarazu-factor 1/nuclear receptor NR5A subfamily, interacts with heterochronic genes that regulate the larva-to-adult transition in C. elegans. We identified nhr-25 as a regulator of apl-1, a homolog of the Alzheimer\u0027s amyloid precursor protein-like gene that is downstream of let-7 family microRNAs. NHR-25 controls not only apl-1 expression but also regulates developmental progression in the larva-to-adult transition. NHR-25 negatively regulates the expression of the adult-specific collagen gene col-19 in lateral epidermal seam cells. In contrast, NHR-25  positively regulates the larva-to-adult transition for other timed events in seam cells, such as cell fusion, cell division and alae formation. The genetic relationships between nhr-25 and other heterochronic genes are strikingly varied among several adult developmental events. We propose that nhr-25 has multiple roles in both promoting and inhibiting the C. elegans heterochronic gene pathway controlling adult differentiation programs.", "subitem_description_type": "Abstract"}]}, "item_5_identifier_34": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2241/106285"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Inc."}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "20678979", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.ydbio.2010.05.508", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2010 Elsevier Inc."}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0012-1606", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00627848", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u30b2\u30ce\u30e0\u79d1\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hada, Kazumasa"}], "nameIdentifiers": [{"nameIdentifier": "71262", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asahina, Masako"}], "nameIdentifiers": [{"nameIdentifier": "71263", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hasegawa, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "71264", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanaho, Yasunori"}], "nameIdentifiers": [{"nameIdentifier": "71265", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Slack, Frank J."}], "nameIdentifiers": [{"nameIdentifier": "71266", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Ryusuke"}], "nameIdentifiers": [{"nameIdentifier": "71267", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-12-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "DB_344-2.pdf", "filesize": [{"value": "4.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4700000.0, "url": {"label": "DB_344-2.pdf", "url": "https://tsukuba.repo.nii.ac.jp/record/20230/files/DB_344-2.pdf"}, "version_id": "88dbbc80-99bc-4962-b921-d29993b7961f"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The nuclear receptor gene nhr-25  plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "The nuclear receptor gene nhr-25  plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition"}]}, "item_type_id": "5", "owner": "1", "path": ["7131/877", "29/1294", "2780/1306", "3/62/5586/579"], "permalink_uri": "http://hdl.handle.net/2241/106285", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2010-09-06"}, "publish_date": "2010-09-06", "publish_status": "0", "recid": "20230", "relation": {}, "relation_version_is_last": true, "title": ["The nuclear receptor gene nhr-25  plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition"], "weko_shared_id": 5}