{"_buckets": {"deposit": "7d05e180-bde4-4181-8eda-261048227060"}, "_deposit": {"created_by": 25, "id": "2002406", "owner": "25", "owners": [25], "pid": {"revision_id": 0, "type": "depid", "value": "2002406"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:02002406", "sets": ["1774", "1777", "334", "1641430982142"]}, "author_link": ["203990", "204843", "76"], "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "971", "bibliographicPageStart": "949", "bibliographicVolumeNumber": "11", "bibliographic_titles": [{"bibliographic_title": "Cellular and Molecular Gastroenterology and Hepatology", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background \u0026 Aims\ncAMP responsive element-binding protein 3 like 3 (CREB3L3) is a membrane-bound transcription factor involved in the maintenance of lipid metabolism in the liver and small intestine. CREB3L3 controls hepatic triglyceride and glucose metabolism by activating plasma fibroblast growth factor 21 (FGF21) and lipoprotein lipase. In this study, we intended to clarify its effect on atherosclerosis.\n\nMethods\nCREB3L3-deficifient, liver-specific CREB3L3 knockout, intestine-specific CREB3L3 knockout, both liver- and intestine-specific CREB3L3 knockout, and liver CREB3L3 transgenic mice were crossed with LDLR−/− mice. These mice were fed with a Western diet to develop atherosclerosis.\n\nResults\nCREB3L3 ablation in LDLR−/− mice exacerbated hyperlipidemia with accumulation of remnant APOB-containing lipoprotein. This led to the development of enhanced aortic atheroma formation, the extent of which was additive between liver- and intestine-specific deletion. Conversely, hepatic nuclear CREB3L3 overexpression markedly suppressed atherosclerosis with amelioration of hyperlipidemia. CREB3L3 directly up-regulates anti-atherogenic FGF21 and APOA4. In contrast, it antagonizes hepatic sterol regulatory element-binding protein (SREBP)–mediated lipogenic and cholesterogenic genes and regulates intestinal liver X receptor–regulated genes involved in the transport of cholesterol. CREB3L3 deficiency results in the accumulation of nuclear SREBP proteins. Because both transcriptional factors share the cleavage system for nuclear transactivation, full-length CREB3L3 and SREBPs in the endoplasmic reticulum (ER) functionally inhibit each other. CREB3L3 promotes the formation of the SREBP-insulin induced gene 1 complex to suppress SREBPs for ER-Golgi transport, resulting in ER retention and inhibition of proteolytic activation at the Golgi and vice versa.\n\nConclusions\nCREB3L3 has multi-potent protective effects against atherosclerosis owing to new mechanistic interaction between CREB3L3 and SREBPs under atherogenic conditions.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "33246135", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.jcmgh.2020.11.004", "subitem_relation_type_select": "DOI"}}]}, "item_5_relation_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.jcmgh.2020.11.004", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2021 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).", "subitem_rights_language": "en"}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2352345X", "subitem_source_identifier_type": "EISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakagawa, Yoshimi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wang, Yunong", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Han, Song-iee", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okuda, Kanako", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Oishi, Asayo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yagishita, Yuka", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kumagai, Kae", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohno, Hiroshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Osaki, Yoshinori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mizunoe, Yuhei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Araki, Masaya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Murayama, Yuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "岩﨑, 仁", "creatorNameLang": "ja"}, {"creatorName": "イワサキ, ヒトシ", "creatorNameLang": "ja-Kana"}, {"creatorName": "IWASAKI, Hitoshi", "creatorNameLang": "en"}], "familyNames": [{"familyName": "岩﨑", "familyNameLang": "ja"}, {"familyName": "イワサキ", "familyNameLang": "ja-Kana"}, {"familyName": "IWASAKI", "familyNameLang": "en"}], "givenNames": [{"givenName": "仁", "givenNameLang": "ja"}, {"givenName": "ヒトシ", "givenNameLang": "ja-Kana"}, {"givenName": "Hitoshi", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "203990", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20626874", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000020626874"}, {"nameIdentifier": "0000003163", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000003163"}]}, {"creatorNames": [{"creatorName": "Konishi, Morichika", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Itoh, Nobuyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "松坂, 賢", "creatorNameLang": "ja"}, {"creatorName": "マツザカ, タカシ", "creatorNameLang": "ja-Kana"}, {"creatorName": "MATSUZAKA, Takashi", "creatorNameLang": "en"}], "familyNames": [{"familyName": "松坂", "familyNameLang": "ja"}, {"familyName": "マツザカ", 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"application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_5", "mimetype": "application/pdf", "size": 5600000.0, "url": {"objectType": "fulltext", "url": "https://tsukuba.repo.nii.ac.jp/record/2002406/files/CMGH_11-4-949.pdf"}, "version_id": "a8efd2d0-ec0e-48a9-baf0-20b7e31686df"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "25", "path": ["1774", "1777", "334", "1641430982142"], "permalink_uri": "http://hdl.handle.net/2241/0002002406", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-01-06"}, "publish_date": "2022-01-06", "publish_status": "0", "recid": "2002406", "relation": {}, "relation_version_is_last": true, "title": ["Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition"], "weko_shared_id": -1}
Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition
http://hdl.handle.net/2241/0002002406
http://hdl.handle.net/2241/0002002406