| Item type |
アイテムタイプJ(1) |
| 公開日 |
2021-12-23 |
| タイトル |
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|
タイトル |
Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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|
資源タイプ |
journal article |
| 著者 |
Tsai, Chia-Jung
Nagata, Takeshi
Liu, Chih-Yao
Suganuma, Takaya
KANDA, Takeshi
Miyazaki, Takehiro
Liu Kai
SAITO, Tsuyoshi
Nagase, Hiroshi
LAZARUS, Michael
VOGT, Kaspar Manuel
YANAGISAWA, Masashi
Hayashi, Yu
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| 著者情報 |
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|
所属・氏名 |
筑波大学; 上田, 壮志; カンダ, タケシ; KANDA, Takeshi |
|
研究者総覧URL |
http://trios.tsukuba.ac.jp/researcher/0000003347 |
| 著者情報 |
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所属・氏名 |
医学医療系; 斉藤, 毅; サイトウ, ツヨシ; SAITO, Tsuyoshi |
|
研究者総覧URL |
http://trios.tsukuba.ac.jp/researcher/0000003353 |
| 著者情報 |
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所属・氏名 |
医学医療系; ラザルス, ミハエル; ラザルス, ミハエル; LAZARUS, Michael |
|
研究者総覧URL |
http://trios.tsukuba.ac.jp/researcher/0000003354 |
| 著者情報 |
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所属・氏名 |
生命環境系; フォークト カスパー, マヌエル; フォークト カスパー, マヌエル; VOGT KASPAR, Manuel |
|
研究者総覧URL |
http://trios.tsukuba.ac.jp/researcher/0000003531 |
| 著者情報 |
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所属・氏名 |
筑波大学; 柳沢, 正史; ヤナギサワ, マサシ; YANAGISAWA, Masashi |
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研究者総覧URL |
http://trios.tsukuba.ac.jp/researcher/0000000016 |
| 抄録 |
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内容記述 |
Sleep is generally viewed as a period of recovery, but how the supply of cerebral blood flow (CBF) changes across sleep/wake states has remained unclear. Here, we directly observe red blood cells (RBCs) within capillaries, where the actual substance exchange between the blood and neurons/glia occurs, by two-photon microscopy. Across multiple cortical areas, average capillary CBF is largely increased during rapid eye movement (REM) sleep, whereas it does not differ between periods of active wakefulness and non-REM sleep. Capillary RBC flow during REM sleep is further elevated following REM sleep deprivation, suggesting that capillary CBF reflects REM sleep pressure. At the molecular level, signaling via adenosine A2a receptors is crucial; in A2a-KO mice, capillary CBF upsurge during REM sleep is dampened, and effects of REM sleep pressure are abolished. These results provide evidence regarding the dynamics of capillary CBF across sleep/wake states and insights to the underlying mechanisms. |
| 書誌情報 |
en : Cell Reports
巻 36,
号 7,
p. 109558,
発行日 2021-08
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| PISSN |
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収録物識別子 |
2211-1247 |
| アクセス権 |
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アクセス権 |
open access |
| 権利情報 |
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|
権利情報 |
© 2021 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| 出版者 |
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出版者 |
Cell Press |
| 出版タイプ |
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出版タイプ |
VoR |
| DOI |
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関連タイプ |
isIdenticalTo |
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関連識別子 |
https://doi.org/10.1016/j.celrep.2021.109558 |
| PMID |
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関連識別子 |
34407410 |
CR_36-7.pdf (3.4 MB)
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