{"_buckets": {"deposit": "ee68c4bc-079b-4da9-9a47-775c0fbb3eb5"}, "_deposit": {"created_by": 14, "id": "2001263", "owner": "14", "owners": [14], "owners_ext": {"displayname": "大久保光枝", "username": "mokubo"}, "pid": {"revision_id": 0, "type": "depid", "value": "2001263"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:02001263", "sets": ["544", "1631596309299"]}, "author_link": ["171"], "control_number": "2001263", "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "19-20", "bibliographicPageEnd": "1053", "bibliographicPageStart": "1043", "bibliographicVolumeNumber": "31", "bibliographic_titles": [{"bibliographic_title": "Human Gene Therapy", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The development of genome-editing technology could lead to breakthrough gene therapy. Genome editing has made it possible to easily knock out or modify a target gene, while current gene therapy using a virus vector or plasmid hampering modification with respect to gene replacement therapies. Clinical development using these genome-editing tools is progressing rapidly. However, it is also becoming clear that there is a possibility of unintended gene sequence modification or deletion, or the insertion of undesired genes, or the selection of cells with abnormalities in the cancer suppressor gene p53; these unwanted actions are not possible with current gene therapy. The Science Board of the Pharmaceuticals and Medical Devices Agency of Japan has compiled a report on the expected aspects of such genome-editing technology and the risks associated with it. This article summarizes the history of that discussion and compares the key concepts with information provided by other regulatory authorities.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Mary Ann Liebert", "subitem_publisher_language": "en"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "32731837", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1089/hum.2020.156", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© Teruhide Yamaguchi et al., 2020; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http:// creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.", "subitem_rights_language": "en"}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1043-0342", "subitem_source_identifier_type": "PISSN"}]}, "item_5_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10805126", "subitem_source_identifier_type": "NCID"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamaguchi, Teruhide", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Uchida Eriko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okada, Takashi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ozawa, Keiya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Onodera, Masafumi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kume, Akihiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Shimada, Takashi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "高橋, 智", "creatorNameLang": "ja"}, {"creatorName": "タカハシ, サトル", "creatorNameLang": "ja-Kana"}, {"creatorName": "TAKAHASHI, Satoru", "creatorNameLang": "en"}], "familyNames": [{"familyName": "高橋", "familyNameLang": "ja"}, {"familyName": "タカハシ", "familyNameLang": "ja-Kana"}, {"familyName": "TAKAHASHI", "familyNameLang": "en"}], "givenNames": [{"givenName": "智", "givenNameLang": "ja"}, {"givenName": "サトル", "givenNameLang": "ja-Kana"}, {"givenName": "Satoru", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "171", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50271896", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000050271896"}, {"nameIdentifier": "0000001614", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001614"}]}, {"creatorNames": [{"creatorName": "Tani, Kenzaburo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nasu, Yasutomo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mashimo, Tomoji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mizuguchi, Hiroyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mitani, Kohnosuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Maki, Kazushige", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-09-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "HGT_31.pdf", "filesize": [{"value": "435 KB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 435000.0, "url": {"objectType": "fulltext", "url": "https://tsukuba.repo.nii.ac.jp/record/2001263/files/HGT_31.pdf"}, "version_id": "ebcebabf-7113-46f4-931f-99bc82024e9a"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "14", "path": ["544", "1631596309299"], "permalink_uri": "http://hdl.handle.net/2241/0002001263", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-09-14"}, "publish_date": "2021-09-14", "publish_status": "0", "recid": "2001263", "relation": {}, "relation_version_is_last": true, "title": ["Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan"], "weko_shared_id": -1}
Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan
http://hdl.handle.net/2241/0002001263
http://hdl.handle.net/2241/0002001263