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Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

http://hdl.handle.net/2241/0002001119
http://hdl.handle.net/2241/0002001119
e516e714-fba2-4f53-a216-685d90b0531d
名前 / ファイル ライセンス アクション
BMCMedicine_19-131.pdf BMCMedicine_19-131.pdf (1.5 MB)
license.icon
Item type アイテムタイプJ(1)
公開日 2021-08-24
タイトル
タイトル Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 Hiwasa Takaki

× Hiwasa Takaki

en Hiwasa Takaki

Wang Hao

× Wang Hao

en Wang Hao

Goto Ken-ichiro

× Goto Ken-ichiro

en Goto Ken-ichiro

Mine Seiichiro

× Mine Seiichiro

en Mine Seiichiro

Machida Toshio

× Machida Toshio

en Machida Toshio

Kobayashi Eiichi

× Kobayashi Eiichi

en Kobayashi Eiichi

Yoshida Yoichi

× Yoshida Yoichi

en Yoshida Yoichi

Adachi Akihiko

× Adachi Akihiko

en Adachi Akihiko

Matsutani Tomoo

× Matsutani Tomoo

en Matsutani Tomoo

Sata Mizuki

× Sata Mizuki

en Sata Mizuki

Kazumasa Yamagishi

× Kazumasa Yamagishi

en Kazumasa Yamagishi

Iso Hiroyasu

× Iso Hiroyasu

en Iso Hiroyasu

Sawada Norie

× Sawada Norie

en Sawada Norie

Tsugane Shoichiro

× Tsugane Shoichiro

en Tsugane Shoichiro

Kunimatsu Mitoshi

× Kunimatsu Mitoshi

en Kunimatsu Mitoshi

Kamitsukasa Ikuo

× Kamitsukasa Ikuo

en Kamitsukasa Ikuo

Mori Masahiro

× Mori Masahiro

en Mori Masahiro

Sugimoto Kazuo

× Sugimoto Kazuo

en Sugimoto Kazuo

Uzawa Akiyuki

× Uzawa Akiyuki

en Uzawa Akiyuki

Muto Mayumi

× Muto Mayumi

en Muto Mayumi

Kuwabara Satoshi

× Kuwabara Satoshi

en Kuwabara Satoshi

Kobayashi Yoshio

× Kobayashi Yoshio

en Kobayashi Yoshio

Ohno Mikiko

× Ohno Mikiko

en Ohno Mikiko

Nishi Eiichiro

× Nishi Eiichiro

en Nishi Eiichiro

Hattori Akiko

× Hattori Akiko

en Hattori Akiko

Yamamoto Masashi

× Yamamoto Masashi

en Yamamoto Masashi

Maezawa Yoshiro

× Maezawa Yoshiro

en Maezawa Yoshiro

Kobayashi Kazuki

× Kobayashi Kazuki

en Kobayashi Kazuki

Ishibashi Ryoichi

× Ishibashi Ryoichi

en Ishibashi Ryoichi

Takemoto Minoru

× Takemoto Minoru

en Takemoto Minoru

Yokote Koutaro

× Yokote Koutaro

en Yokote Koutaro

Takizawa Hirotaka

× Takizawa Hirotaka

en Takizawa Hirotaka

Kishimoto Takashi

× Kishimoto Takashi

en Kishimoto Takashi

Matsushita Kazuyuki

× Matsushita Kazuyuki

en Matsushita Kazuyuki

Kobayashi Sohei

× Kobayashi Sohei

en Kobayashi Sohei

Nomura Fumio

× Nomura Fumio

en Nomura Fumio

Arasawa Takahiro

× Arasawa Takahiro

en Arasawa Takahiro

Kagaya Akiko

× Kagaya Akiko

en Kagaya Akiko

Maruyama Tetsuro

× Maruyama Tetsuro

en Maruyama Tetsuro

Matsubara Hisahiro

× Matsubara Hisahiro

en Matsubara Hisahiro

Tomiita Minako

× Tomiita Minako

en Tomiita Minako

Hamanaka Shinsaku

× Hamanaka Shinsaku

en Hamanaka Shinsaku

Imai Yushi

× Imai Yushi

en Imai Yushi

Nakagawa Tomoo

× Nakagawa Tomoo

en Nakagawa Tomoo

Kato Naoya

× Kato Naoya

en Kato Naoya

Terada Jiro

× Terada Jiro

en Terada Jiro

Matsumura Takuma

× Matsumura Takuma

en Matsumura Takuma

Katsumata Yusuke

× Katsumata Yusuke

en Katsumata Yusuke

Naito Akira

× Naito Akira

en Naito Akira

Tanabe Nobuhiro

× Tanabe Nobuhiro

en Tanabe Nobuhiro

Sakao Seiichiro

× Sakao Seiichiro

en Sakao Seiichiro

Tatsumi Koichiro

× Tatsumi Koichiro

en Tatsumi Koichiro

Ito Masaaki

× Ito Masaaki

en Ito Masaaki

Shiratori Fumiaki

× Shiratori Fumiaki

en Shiratori Fumiaki

Sumazaki Makoto

× Sumazaki Makoto

en Sumazaki Makoto

Yajima Satoshi

× Yajima Satoshi

en Yajima Satoshi

Shimada Hideaki

× Shimada Hideaki

en Shimada Hideaki

Shirouzu Mikako

× Shirouzu Mikako

en Shirouzu Mikako

Yokoyama Shigeyuki

× Yokoyama Shigeyuki

en Yokoyama Shigeyuki

Kudo Takashi

× Kudo Takashi

en Kudo Takashi

Doi Hirofumi

× Doi Hirofumi

en Doi Hirofumi

Iwase Katsuro

× Iwase Katsuro

en Iwase Katsuro

Ashino Hiromi

× Ashino Hiromi

en Ashino Hiromi

Li Shu-Yang

× Li Shu-Yang

en Li Shu-Yang

Kubota Masaaki

× Kubota Masaaki

en Kubota Masaaki

Tomiyoshi Go

× Tomiyoshi Go

en Tomiyoshi Go

Shinmen Natsuko

× Shinmen Natsuko

en Shinmen Natsuko

Nakamura Rika

× Nakamura Rika

en Nakamura Rika

Kuroda Hideyuki

× Kuroda Hideyuki

en Kuroda Hideyuki

Iwadate Yasuo

× Iwadate Yasuo

en Iwadate Yasuo

著者情報
所属・氏名 医学医療系; 山岸, 良匡; ヤマギシ, カズマサ; YAMAGISHI, Kazumasa
研究者総覧URL http://trios.tsukuba.ac.jp/researcher/0000001615
抄録
内容記述 Background
Acute ischemic stroke (AIS) is a serious cause of mortality and disability. AIS is a serious cause of mortality and disability. Early diagnosis of atherosclerosis, which is the major cause of AIS, allows therapeutic intervention before the onset, leading to prevention of AIS.

Methods
Serological identification by cDNA expression cDNA libraries and the protein array method were used for the screening of antigens recognized by serum IgG antibodies in patients with atherosclerosis. Recombinant proteins or synthetic peptides derived from candidate antigens were used as antigens to compare serum IgG levels between healthy donors (HDs) and patients with atherosclerosis-related disease using the amplified luminescent proximity homogeneous assay-linked immunosorbent assay.

Results
The first screening using the protein array method identified death-inducer obliterator 1 (DIDO1), forkhead box J2 (FOXJ2), and cleavage and polyadenylation specificity factor (CPSF2) as the target antigens of serum IgG antibodies in patients with AIS. Then, we prepared various antigens including glutathione S-transferase-fused DIDO1 protein as well as peptides of the amino acids 297–311 of DIDO1, 426–440 of FOXJ2, and 607–621 of CPSF2 to examine serum antibody levels. Compared with HDs, a significant increase in antibody levels of the DIDO1 protein and peptide in patients with AIS, transient ischemic attack (TIA), and chronic kidney disease (CKD) but not in those with acute myocardial infarction and diabetes mellitus (DM). Serum anti-FOXJ2 antibody levels were elevated in most patients with atherosclerosis-related diseases, whereas serum anti-CPSF2 antibody levels were associated with AIS, TIA, and DM. Receiver operating characteristic curves showed that serum DIDO1 antibody levels were highly associated with CKD, and correlation analysis revealed that serum anti-FOXJ2 antibody levels were associated with hypertension. A prospective case–control study on ischemic stroke verified that the serum antibody levels of the DIDO1 protein and DIDO1, FOXJ2, and CPSF2 peptides showed significantly higher odds ratios with a risk of AIS in patients with the highest quartile than in those with the lowest quartile, indicating that these antibody markers are useful as risk factors for AIS.

Conclusions
Serum antibody levels of DIDO1, FOXJ2, and CPSF2 are useful in predicting the onset of atherosclerosis-related AIS caused by kidney failure, hypertension, and DM, respectively.
書誌情報 en : BMC medicine

巻 19, p. 131, 発行日 2021-06
PISSN
収録物識別子 1741-7015
NCID
収録物識別子 AA12035245
アクセス権
アクセス権 open access
権利情報
権利情報 © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
出版者
出版者 BioMed Central
出版タイプ
出版タイプ VoR
DOI
関連タイプ isIdenticalTo
関連識別子 https://doi.org/10.1186/s12916-021-02001-9
PMID
関連識別子 34103026
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