ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To

Field does not validate



インデックスリンク

インデックスツリー

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "96367d2d-74cb-4d11-8d62-c21b7e1e3400"}, "_deposit": {"id": "18212", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18212"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00018212"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "1045", "bibliographicPageStart": "1041", "bibliographicVolumeNumber": "24", "bibliographic_titles": [{"bibliographic_title": "Pediatric surgery international"}]}]}, "item_5_creator_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u74dc\u7530, \u6cf0\u4e45"}], "nameIdentifiers": [{"nameIdentifier": "204020", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90361352", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000090361352"}, {"nameIdentifier": "0000002326", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000002326"}]}, {"creatorNames": [{"creatorName": "\u5c0f\u5ba4, \u5e83\u662d"}], "nameIdentifiers": [{"nameIdentifier": "65141", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u91d1\u5b50, \u9053\u592b"}], "nameIdentifiers": [{"nameIdentifier": "65142", "nameIdentifierScheme": "WEKO"}]}]}, "item_5_description_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Patch closure is necessary to achieve tension-free repair in large congenital diaphragmatic hernia. However, the use of prosthetic material may lead to granulation, allergic reaction, infection, recurrence of hernia, and thoracic deformity. Tissue engineering may become an alternative treatment strategy for diaphragmatic hernia repair, since the regenerated autologous tissue is expected to grow potentially without rejection or infection. We evaluated the efficacy of diaphragmatic hernia repair in a rat model using a poly-lactic-co-glycolic acid (PLGA) mesh\u2013collagen sponge hybrid scaffold, designed for in situ tissue engineering. Twenty-four F344 female rats were used. Oval-shaped defects were surgically created in the left diaphragm and repaired with three different grafts, including PLGA mesh in group 1 (n = 7), PLGA mesh\u2013collagen sponge hybrid scaffold in group 2 (n = 7), and PLGA mesh\u2013collagen sponge hybrid scaffold seeded with bone marrow-derived mesenchymal stem cells (MSCs) in group 3 (n = 10). The animals were killed at 1, 2, and 3 months after operation. The specimens were examined macroscopically and microscopically. No recurrence or eventration was observed. In all animals, autologous fibrous tissue with vascularization was generated at the graft site. Although no muscular tissue was detected, scattered desmin-positive cells were observed in groups 2 and 3. The \u2018neodiaphragm\u2019 in groups 2 and 3 was significantly thicker compared with that in group 1. There was no significant difference in the \u2018neodiaphragm\u2019 between groups 2 and 3. The PLGA mesh\u2013collagen sponge hybrid scaffold provided better promotion of autologous in situ tissue regeneration in the diaphragm, suggesting its potential application to diaphragmatic repair in place of other prosthetic patches.", "subitem_description_type": "Abstract"}]}, "item_5_identifier_34": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2241/103669"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Springer Verlag"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "18668247", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s00383-008-2212-y", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 Springer-Verlag 2008"}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0179-0358", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1068249X", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u533b\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Urita, Yasuhisa"}], "nameIdentifiers": [{"nameIdentifier": "65134", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komuro, Hiroaki"}], "nameIdentifiers": [{"nameIdentifier": "65135", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chen, Guoping"}], "nameIdentifiers": [{"nameIdentifier": "65136", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinya, Miki"}], "nameIdentifiers": [{"nameIdentifier": "65137", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saihara, Ryoko"}], "nameIdentifiers": [{"nameIdentifier": "65138", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaneko, Michio"}], "nameIdentifiers": [{"nameIdentifier": "65139", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-12-19"}], "displaytype": "detail", "download_preview_message": "", "filename": "PSI_24-9.pdf", "filesize": [{"value": "303.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3034000, "url": {"label": "PSI_24-9.pdf", "url": "https://tsukuba.repo.nii.ac.jp/record/18212/files/PSI_24-9.pdf"}, "version_id": "fce9445b-f54f-43f6-aaef-502ee51a41f8"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Evaluation of diaphragmatic hernia repair using PLGA mesh\u2013collagen sponge hybrid scaffold: an experimental study in a rat model", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Evaluation of diaphragmatic hernia repair using PLGA mesh\u2013collagen sponge hybrid scaffold: an experimental study in a rat model"}]}, "item_type_id": "5", "owner": "1", "path": ["2780/1304", "2871/2876/546", "2871/2876/545", "3/62/5598/1124"], "permalink_uri": "http://hdl.handle.net/2241/103669", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2009-09-24"}, "publish_date": "2009-09-24", "publish_status": "0", "recid": "18212", "relation": {}, "relation_version_is_last": true, "title": ["Evaluation of diaphragmatic hernia repair using PLGA mesh\u2013collagen sponge hybrid scaffold: an experimental study in a rat model"], "weko_shared_id": 5}
  1. 医学医療系 (Faculty of Medicine)
  2. 瓜田 泰久 (Urita Yasuhisa)
  1. 研究科 (Graduate School)
  2. 人間総合科学研究科 (Graduate School of Comprehensive Human Sciences)
  3. 小室 広昭 (Komuro Hiroaki)
  1. 研究科 (Graduate School)
  2. 人間総合科学研究科 (Graduate School of Comprehensive Human Sciences)
  3. 金子 道夫 (Kaneko Michio)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. P~
  4. Pediatric surgery international

Evaluation of diaphragmatic hernia repair using PLGA mesh–collagen sponge hybrid scaffold: an experimental study in a rat model

http://hdl.handle.net/2241/103669
5a73028d-9cc5-48e6-bf96-e664f5fe5469
プレビュー
名前 / ファイル ライセンス Actions
PSI_24-9.pdf PSI_24-9.pdf (303.4 kB)
item type Journal Article(1)
公開日 2009-09-24
タイトル
タイトル Evaluation of diaphragmatic hernia repair using PLGA mesh–collagen sponge hybrid scaffold: an experimental study in a rat model
言語
言語 eng
資源タイプ
タイプ journal article
著者 Urita, Yasuhisa

× Urita, Yasuhisa

WEKO 65134

Urita, Yasuhisa

Search repository
Komuro, Hiroaki

× Komuro, Hiroaki

WEKO 65135

Komuro, Hiroaki

Search repository
Chen, Guoping

× Chen, Guoping

WEKO 65136

Chen, Guoping

Search repository
Shinya, Miki

× Shinya, Miki

WEKO 65137

Shinya, Miki

Search repository
Saihara, Ryoko

× Saihara, Ryoko

WEKO 65138

Saihara, Ryoko

Search repository
Kaneko, Michio

× Kaneko, Michio

WEKO 65139

Kaneko, Michio

Search repository
著者別名 瓜田, 泰久

× 瓜田, 泰久

WEKO 204020
e-Rad 90361352
筑波大学研究者総覧 0000002326

瓜田, 泰久

Search repository
小室, 広昭

× 小室, 広昭

WEKO 65141

小室, 広昭

Search repository
金子, 道夫

× 金子, 道夫

WEKO 65142

金子, 道夫

Search repository
抄録
内容記述 Patch closure is necessary to achieve tension-free repair in large congenital diaphragmatic hernia. However, the use of prosthetic material may lead to granulation, allergic reaction, infection, recurrence of hernia, and thoracic deformity. Tissue engineering may become an alternative treatment strategy for diaphragmatic hernia repair, since the regenerated autologous tissue is expected to grow potentially without rejection or infection. We evaluated the efficacy of diaphragmatic hernia repair in a rat model using a poly-lactic-co-glycolic acid (PLGA) mesh–collagen sponge hybrid scaffold, designed for in situ tissue engineering. Twenty-four F344 female rats were used. Oval-shaped defects were surgically created in the left diaphragm and repaired with three different grafts, including PLGA mesh in group 1 (n = 7), PLGA mesh–collagen sponge hybrid scaffold in group 2 (n = 7), and PLGA mesh–collagen sponge hybrid scaffold seeded with bone marrow-derived mesenchymal stem cells (MSCs) in group 3 (n = 10). The animals were killed at 1, 2, and 3 months after operation. The specimens were examined macroscopically and microscopically. No recurrence or eventration was observed. In all animals, autologous fibrous tissue with vascularization was generated at the graft site. Although no muscular tissue was detected, scattered desmin-positive cells were observed in groups 2 and 3. The ‘neodiaphragm’ in groups 2 and 3 was significantly thicker compared with that in group 1. There was no significant difference in the ‘neodiaphragm’ between groups 2 and 3. The PLGA mesh–collagen sponge hybrid scaffold provided better promotion of autologous in situ tissue regeneration in the diaphragm, suggesting its potential application to diaphragmatic repair in place of other prosthetic patches.
書誌情報 Pediatric surgery international

巻 24, 号 9, p. 1041-1045, 発行日 2008-09
ISSN
収録物識別子 0179-0358
書誌レコードID
収録物識別子 AA1068249X
PubMed番号
関連識別子
関連識別子 18668247
DOI
関連識別子
関連識別子 10.1007/s00383-008-2212-y
権利
権利情報 © Springer-Verlag 2008
著者版フラグ
値 author
出版者
出版者 Springer Verlag
Back
0
views
See details
Views

Versions

Ver.1 2021-03-01 20:43:10.519714
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio