{"_buckets": {"deposit": "1639bcf0-5816-4d05-907c-7efb713cb86d"}, "_deposit": {"id": "17983", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "17983"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00017983"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "976", "bibliographicPageStart": "974", "bibliographicVolumeNumber": "93", "bibliographic_titles": [{"bibliographic_title": "British journal of ophthalmology"}]}]}, "item_5_creator_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u52a0\u6cbb, \u512a\u4e00"}], "nameIdentifiers": [{"nameIdentifier": "344", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50361332", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000050361332"}, {"nameIdentifier": "0000001737", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001737"}]}, {"creatorNames": [{"creatorName": "\u5927\u9e7f, \u54f2\u90ce"}], "nameIdentifiers": [{"nameIdentifier": "605", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90194133", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000090194133"}, {"nameIdentifier": "0000001779", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001779"}]}, {"creatorNames": [{"creatorName": "\u5ca1\u672c, \u53f2\u6a39"}], "nameIdentifiers": [{"nameIdentifier": "374", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30334064", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000030334064"}, {"nameIdentifier": "0000001806", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001806"}]}]}, "item_5_description_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Background: D-\u03b2-Aspartic acid residues, which are biologically uncommon, have been reported to accumulate in various proteins of the living body with age. In the present study, D-\u03b2-aspartic acid-containing proteins were found to be localised in pingueculae, which represent one of the most prominent age-related ocular changes.\n\nMethods: Surgical specimens of conjunctivae with or without pingueculae were obtained from eight patients. Immunohistochemical localisation of D-\u03b2-aspartic acid-containing proteins was performed using a polyclonal antibody against D-\u03b2-aspartic acid-containing peptides.\n\nResults: Strong immunoreactivity to D-\u03b2-aspartic acid-containing peptides was detected in the subepithelial amorphous materials of all surgical specimens with pingueculae. In contrast, no immunoreactivity to D-\u03b2-aspartic acid-containing peptides was detected in the specimens without pingueculae.\n\nConclusions: Pingueculae are thought to be aggregates of proteins that contain D-\u03b2-aspartic acid residues. It is known that the conversion of L- to D-aspartyl residues is accelerated by ultraviolet irradiation. In addition, D-\u03b2-aspartic acid-containing proteins, in general, tend to aggregate with each other and accumulate in the tissues. These facts indicate that ultraviolet irradiation-induced racemisation of aspartic acid is closely related to the development of pingueculae.", "subitem_description_type": "Abstract"}]}, "item_5_identifier_34": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2241/103162"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "BMJ Publishing Group"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "19276098", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1136/bjo.2007.135889", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2009 by the BMJ Publishing Group Ltd."}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0007-1161", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00574774", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u533b\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kaji, Y"}], "nameIdentifiers": [{"nameIdentifier": "63951", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oshika, T"}], "nameIdentifiers": [{"nameIdentifier": "63952", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okamoto, F"}], "nameIdentifiers": [{"nameIdentifier": "63953", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujii, N"}], "nameIdentifiers": [{"nameIdentifier": "63954", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-12-19"}], "displaytype": "detail", "download_preview_message": "", "filename": "BJO_93-7_1.pdf", "filesize": [{"value": "631.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 6319000, "url": {"label": "BJO_93-7_1.pdf", "url": "https://tsukuba.repo.nii.ac.jp/record/17983/files/BJO_93-7_1.pdf"}, "version_id": "0cca284e-c338-4288-a1b9-95e755eb09e3"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Immunohistochemical localisation of d-\u03b2-aspartic acid in pingueculae", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Immunohistochemical localisation of d-\u03b2-aspartic acid in pingueculae"}]}, "item_type_id": "5", "owner": "1", "path": ["2780/960", "2780/962", "2780/954", "3/62/5297/575"], "permalink_uri": "http://hdl.handle.net/2241/103162", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2009-07-24"}, "publish_date": "2009-07-24", "publish_status": "0", "recid": "17983", "relation": {}, "relation_version_is_last": true, "title": ["Immunohistochemical localisation of d-\u03b2-aspartic acid in pingueculae"], "weko_shared_id": 5}