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Macrophage colony-stimulating factor regulates both activities of neutral and acidic cholesteryl ester hydrolases in human monocyte-derived macrophages
http://hdl.handle.net/2241/102308
http://hdl.handle.net/2241/102308d3d9adb7-867c-4c7d-ad43-509b2179154d
名前 / ファイル | ライセンス | アクション |
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JCI_92-2.pdf (1.8 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2009-04-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Macrophage colony-stimulating factor regulates both activities of neutral and acidic cholesteryl ester hydrolases in human monocyte-derived macrophages | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Inaba, Toshimori
× Inaba, Toshimori× Shimano, Hitoshi× Gotoda, Takanari× Harada, Kenji× Shimada, Masako× Kawamura, Masako× Yazaki, Yoshio× 山田, 信博 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Macrophage colony-stimulating factor (M-CSF) regulates cholesterol metabolism in vivo and in vitro. We studied the effects of M-CSF on enzyme activities of acidic cholesteryl ester (CE) hydrolase, neutral CE hydrolase, and acyl-coenzyme A:cholesterol acyltransferase (ACAT), all of which are involved in cellular cholesterol metabolism in macrophages. During the differentiation of monocytes to macrophages, these enzyme activities were induced and further enhanced in response to M-CSF. M-CSF (100 ng/ml) enhanced acidic and neutral CE hydrolase and ACAT activities by 3.2-, 4-, and 2.3-fold, respectively, in the presence of acetyl LDL. The presence of acetyl LDL influenced these enzyme activities. ACAT and acidic CE hydrolase activities were increased and neutral CE hydrolase activity was decreased, indicating that these enzymes are regulated by intracellular cholesterol enrichment. M-CSF increased the ratios of acidic CE hydrolase to ACAT activity and of neutral CE hydrolase to ACAT activity. The results suggest that M-CSF enhances net hydrolysis of CE by stimulating the two CE hydrolases to a greater extent than ACAT, and M-CSF may reduce the rate of atherogenesis. | |||||
言語 | en | |||||
書誌情報 |
en : The journal of clinical investigation 巻 92, 号 2, p. 750-757, 発行日 1993-08 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0021-9738 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 8394386 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1172/JCI116646 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © The American Society for Clinical Investigation | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | The American Society for Clinical Investigation |