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PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity
http://hdl.handle.net/2241/102302
http://hdl.handle.net/2241/1023020101c7a1-df82-4663-9ed8-e67a3aa9b1f2
名前 / ファイル | ライセンス | アクション |
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JCI_112-6.pdf (1.9 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2009-04-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Matsumoto, Michihiro
× Matsumoto, Michihiro× Ogawa, Wataru× Akimoto, Kazunori× Inoue, Hiroshi× Miyake, Kazuaki× Furukawa, Kensuke× Hayashi, Yoshitake× Iguchi, Haruhisa× Matsuki, Yasushi× Hiramatsu, Ryuji× 島野, 仁× 山田, 信博× Ohno, Shigeo× Kasuga, Masato× Noda, Tetsuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PKCλ is implicated as a downstream effector of PI3K in insulin action. We show here that mice that lack PKCλ specifically in the liver (L-λKO mice), produced with the use of the Cre-loxP system, exhibit increased insulin sensitivity as well as a decreased triglyceride content and reduced expression of the sterol regulatory element?binding protein-1c (SREBP-1c) gene in the liver. Induction of the hepatic expression of Srebp1c and of its target genes involved in fatty acid/triglyceride synthesis by fasting and refeeding or by hepatic expression of an active form of PI3K was inhibited in L-λKO mice compared with that in control animals. Expression of Srebp1c induced by insulin or by active PI3K in primary cultured rat hepatocytes was inhibited by a dominant-negative form of PKCλ and was mimicked by overexpression of WT PKCλ. Restoration of PKCλ expression in the liver of L-λKO mice with the use of adenovirus-mediated gene transfer corrected the metabolic abnormalities of these animals. Hepatic PKCλ is thus a determinant of hepatic lipid content and whole-body insulin sensitivity. | |||||
言語 | en | |||||
書誌情報 |
en : The journal of clinical investigation 巻 112, 号 6, p. 935-944, 発行日 2003-09 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0021-9738 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 12975478 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1172/JCI18816 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2003, The American Society for Clinical Investigation | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | The American Society for Clinical Investigation |