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Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.
http://hdl.handle.net/2241/102293
http://hdl.handle.net/2241/1022930480bbf5-38fb-476a-b05e-fa42d5b7aeea
名前 / ファイル | ライセンス | アクション |
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JCI_102-2.pdf (341.3 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2009-04-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Osuga, Jun-ichi
× Osuga, Jun-ichi× Yonemoto, Mari× 山田, 信博× Shimano, Hitoshi× Yagyu, Hiroaki× Ohashi, Ken× Harada, Kenji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Apo E is a key molecule in the lipoprotein metabolism; thus, genetic manipulation of apo E may prove useful in the treatment of hypercholesterolemia. To test the feasibility of this idea, we have generated low density lipoprotein receptor (LDLR) knockout mice that overexpress the rat apo E transgene (ETg+/+:LDLRKO), and compared their plasma lipoprotein profiles with those of nonexpressing LDLR knockout mice (ETg-/-:LDLRKO). On a normal chow diet, the mean plasma cholesterol level of ETg+/+:LDLRKO mice was significantly lower than that of ETg-/-:LDLRKO mice (189 versus 240 mg/dl, P < 0. 01). The LDL fraction was selectively reduced in the ETg+/+:LDLRKO mice. Despite the challenge with an atherogenic diet, cholesterol lowering was persistently observed and fatty streak lesions in the aortic sinus were significantly suppressed in the mice overexpressing apo E. These results imply that stimulation of hepatic production of apo E may be used as a promising adjunctive therapy for homozygous familial hypercholesterolemia. | |||||
言語 | en | |||||
書誌情報 |
en : The journal of clinical investigation 巻 102, 号 2, p. 386-394, 発行日 1998-07 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0021-9738 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 9664080 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1172/JCI1124 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © The American Society for Clinical Investigation | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | The American Society for Clinical Investigation |