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DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes
http://hdl.handle.net/2241/102273
http://hdl.handle.net/2241/10227399e7bd2e-6c60-4075-a758-31d03fd0203c
名前 / ファイル | ライセンス | アクション |
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Immunity_4-6.pdf (87.8 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2009-04-15 | |||||
タイトル | ||||||
タイトル | DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
渋谷, 彰
× 渋谷, 彰× Campbell, David× Hannum, Charles× Yssel, Hans× Franz-Bacon, Karin× Terrill, McClanahan× Kitamura, Toshio× Nicholl, Jillian× Sutherland, Grant R× Lanie, Lewis L× Phillips, Joseph H |
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抄録 | ||||||
内容記述 | Intercellular adhesion molecules play an important role in the generation of T lymphocytemediated immune responses. Here, we describe a novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes. DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa includ- ing two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK cellmediated cytotoxicity against a variety of tumor cell targets and blocks cytokine production by alloanti- gen-specific T cells. In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)mediated cytotoxicity. | |||||
書誌情報 |
en : Immunity 巻 4, 号 6, p. 573-581, 発行日 1996-06 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1074-7613 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11006671 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | https://doi.org/10.1016/S1074-7613(00)70060-4 | |||||
PMID | ||||||
関連識別子 | 08673704 | |||||
権利情報 | ||||||
権利情報 | © 1996 Cell Press | |||||
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出版タイプ | AM | |||||
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出版者 | Elsevier (Cell Press) |