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However, it remains undetermined whether DNAM-1 is involved in tumor immune surveillance in vivo. We addressed this question by using DNAM-1\u2013deficient mice. DNAM-1\u2013deficient cytotoxic T lymphocyte (CTL) and NK cells showed significantly less cytotoxic activity against DNAM-1 ligand-expressing tumors in vitro than wild-type (WT) cells. The methylcholanthrene (MCA)-induced fibrosarcoma cell line Meth A expressed the DNAM-1 ligand CD155, and DNAM-1\u2013deficient mice showed increased tumor development and mortality after transplantation of Meth A cells. Moreover, the DNAM-1\u2013deficient mice developed significantly more DNAM-1 ligand-expressing fibrosarcoma and papilloma cells in response to the chemical carcinogens MCA and 7,12-dimethylbenz[a]anthracene (DMBA), respectively, than did WT mice. These results indicate that DNAM-1 plays an important role in immune surveillance of tumor development.", "subitem_description_type": "Abstract"}]}, "item_5_identifier_34": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2241/102716"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "The Rockefeller University Press"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "19029379", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1084/jem.20081611", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2008 Iguchi-Manaka et al."}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-1007", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00697559", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u533b\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Iguchi-Manaka, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "61998", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kai, Hirayasu"}], "nameIdentifiers": [{"nameIdentifier": "61999", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamashita, Yumi"}], "nameIdentifiers": [{"nameIdentifier": "62000", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata, Kai"}], "nameIdentifiers": [{"nameIdentifier": "62001", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tahara-Hanaoka, Satoko"}], "nameIdentifiers": [{"nameIdentifier": "62002", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Honda, Shin-ichiro"}], "nameIdentifiers": [{"nameIdentifier": "62003", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasui, Teruhito"}], "nameIdentifiers": [{"nameIdentifier": "62004", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikutani, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "62005", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibuya, Kazuko"}], "nameIdentifiers": [{"nameIdentifier": "62006", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibuya, Akira"}], "nameIdentifiers": [{"nameIdentifier": "62007", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-12-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JEM_205-13.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "JEM_205-13.pdf", "url": "https://tsukuba.repo.nii.ac.jp/record/17483/files/JEM_205-13.pdf"}, "version_id": "2ecb2c93-5d18-4432-8954-4374a98040da"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Accelerated tumor growth in mice deficient in DNAM-1 receptor", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Accelerated tumor growth in mice deficient in DNAM-1 receptor"}]}, "item_type_id": "5", "owner": "1", "path": ["7131/543", "7131/988", "2780/989", "2780/987", "2780/984", "3/62/5592/622"], "permalink_uri": "http://hdl.handle.net/2241/102716", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2009-06-03"}, "publish_date": "2009-06-03", "publish_status": "0", "recid": "17483", "relation": {}, "relation_version_is_last": true, "title": ["Accelerated tumor growth in mice deficient in DNAM-1 receptor"], "weko_shared_id": 5}