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Effects of daily aspirin on cancer incidence and mortality in the elderly Japanese
http://hdl.handle.net/2241/00157623
http://hdl.handle.net/2241/0015762312adcf94-767d-47c1-89e2-c96ce5eda2b7
名前 / ファイル | ライセンス | アクション |
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RPTH_2-274 (501.5 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-08-30 | |||||
タイトル | ||||||
タイトル | Effects of daily aspirin on cancer incidence and mortality in the elderly Japanese | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
溝上, 裕士
× 溝上, 裕士× Yokoyama, Kenji× Ishizuka, Naoki× Uemura, Naomi× Hiraishi, Hideyuki× Murata, Mitsuru× Uchiyama, Shinichiro× Teramoto, Tamio× Shimada, Kazuyuki× Yamazaki, Tsutomu× Oikawa, Shinichi× Sugawara, Masahiro× Ando, Katsuyuki× Ikeda, Yasuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background Long‐term follow‐up of studies to investigate preventive effects of aspirin on arterial thrombosis indicate that aspirin reduces the incidence and mortality of some cancers in Western populations. Objectives To explore the effects of aspirin on cancer incidence and mortality in the elderly Japanese. Patients/Methods Patients aged 60 to 85 years, presenting with hypertension, dyslipidemia, or diabetes mellitus (n = 14 601, 7297 in the aspirin group and 7304 in the no‐aspirin group) participated the Japanese Primary Prevention Project (JPPP), a multicenter, open‐label, randomized, parallel‐group trial. A subanalysis of JPPP was performed to analyze the incidence of newly diagnosed cancer and death related to cancer. Results The cumulative incidence of newly diagnosed cancer was 5.60% (4.65‐6.64%) in the aspirin group and 4.14% (3.67‐4.66%) in the no‐aspirin group. The hazard ratio for newly diagnosed cancer was 1.24 (1.06‐1.46), and the cancer incidence was significantly higher in the aspirin group. The cumulative cancer mortality was 1.96% (1.65‐2.31%) in the aspirin group and 1.87% (1.56‐2.22%) in the no‐aspirin group, with no statistically significant difference. The Fine and Gray model suggested that the difference in the incidence of newly diagnosed cancer between the two groups decreased year by year. Conclusions Low‐dose aspirin use did not reduce the cancer incidence or cancer mortality during a 5‐year‐average study period in the elderly Japanese. The cancer incidence in the aspirin group might decrease, however, to less than that in the no‐aspirin group after the study period. Aspirin use might have led to earlier cancer diagnosis in our study. |
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書誌情報 |
Research and Practice in Thrombosis and Haemostasis 巻 2, 号 2, p. 274-281, 発行日 2018-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 24750379 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30046729 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/rth2.12097 | |||||
権利 | ||||||
権利情報 | © 2018 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals, Inc on behalf of International Society on Thrombosis and Haemostasis. | |||||
権利 | ||||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Wiley |