@article{oai:tsukuba.repo.nii.ac.jp:00052195,
 author = {溝上, 裕士 and MIZOKAMI, Yuji and Yokoyama, Kenji and Ishizuka, Naoki and Uemura, Naomi and Hiraishi, Hideyuki and Murata, Mitsuru and Uchiyama, Shinichiro and Teramoto, Tamio and Shimada, Kazuyuki and Yamazaki, Tsutomu and Oikawa, Shinichi and Sugawara, Masahiro and Ando, Katsuyuki and Ikeda, Yasuo},
 issue = {2},
 journal = {Research and Practice in Thrombosis and Haemostasis},
 month = {Apr},
 note = {Background

Long‐term follow‐up of studies to investigate preventive effects of aspirin on arterial thrombosis indicate that aspirin reduces the incidence and mortality of some cancers in Western populations.

Objectives

To explore the effects of aspirin on cancer incidence and mortality in the elderly Japanese.

Patients/Methods

Patients aged 60 to 85 years, presenting with hypertension, dyslipidemia, or diabetes mellitus (n = 14 601, 7297 in the aspirin group and 7304 in the no‐aspirin group) participated the Japanese Primary Prevention Project (JPPP), a multicenter, open‐label, randomized, parallel‐group trial. A subanalysis of JPPP was performed to analyze the incidence of newly diagnosed cancer and death related to cancer.

Results

The cumulative incidence of newly diagnosed cancer was 5.60% (4.65‐6.64%) in the aspirin group and 4.14% (3.67‐4.66%) in the no‐aspirin group. The hazard ratio for newly diagnosed cancer was 1.24 (1.06‐1.46), and the cancer incidence was significantly higher in the aspirin group. The cumulative cancer mortality was 1.96% (1.65‐2.31%) in the aspirin group and 1.87% (1.56‐2.22%) in the no‐aspirin group, with no statistically significant difference. The Fine and Gray model suggested that the difference in the incidence of newly diagnosed cancer between the two groups decreased year by year.

Conclusions

Low‐dose aspirin use did not reduce the cancer incidence or cancer mortality during a 5‐year‐average study period in the elderly Japanese. The cancer incidence in the aspirin group might decrease, however, to less than that in the no‐aspirin group after the study period. Aspirin use might have led to earlier cancer diagnosis in our study.},
 pages = {274--281},
 title = {Effects of daily aspirin on cancer incidence and mortality in the elderly Japanese},
 volume = {2},
 year = {2018},
 yomi = {ミゾカミ, ユウジ}
}