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Redox toxicology of environmental chemicals causing oxidative stress
http://hdl.handle.net/2241/00161612
http://hdl.handle.net/2241/00161612e9d33c9b-dd60-472a-82a6-d1772bf903f2
名前 / ファイル | ライセンス | アクション |
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RB_34-101475 (1.1 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-10-19 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Redox toxicology of environmental chemicals causing oxidative stress | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
安孫子, ユミ
× 安孫子, ユミ× 熊谷, 嘉人× Zheng, Fuli× Gonçalves, Filipe Marques× Li, Huangyuan× Aschner, Michael |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or atmospheric pollutants such as quinone. Extensive studies have demonstrated a strong link between environmental pollutants and human health. Redox toxicity is proposed as one of the main mechanisms of chemical-induced pathology in humans. Acting as both a sensor of oxidative stress and a positive regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) has attracted recent attention. However, the role NRF2 plays in environmental pollutant-induced toxicity has not been systematically addressed. Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. NRF2 related signaling pathways and epigenetic regulations are also reviewed. | |||||
書誌情報 |
en : Redox Biology 巻 34, p. 101475, 発行日 2020-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 22132317 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32336668 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.redox.2020.101475 | |||||
権利 | ||||||
権利情報 | © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Elsevier |