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Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules
http://hdl.handle.net/2241/00159739
http://hdl.handle.net/2241/00159739738f1749-d0a9-46a3-b361-d47821abba47
名前 / ファイル | ライセンス | アクション |
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TR_35-4 (585.4 kB)
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Item type | Journal Article(1) | |||||||||||
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公開日 | 2020-03-17 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
タイプ | journal article | |||||||||||
著者 |
熊谷, 嘉人
× 熊谷, 嘉人× 秋山, 雅博
WEKO
203869
× Unoki, Takamitsu |
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | We are exposed to numerous xenobiotic electrophiles on a daily basis through the environment, lifestyle, and dietary habits. Although such reactive species have been associated with detrimental effects, recent accumulated evidence indicates that xenobiotic electrophiles appear to act as signaling molecules. In this review, we introduce our findings on 1) activation of various redox signaling pathways involved in cell proliferation, detoxification/excretion of electrophiles, quality control of cellular proteins, and cell survival during exposure to xenobiotic electrophiles at low concentrations through covalent modification of thiol groups in sensor proteins, and 2) negative regulation of reactive sulfur species (RSS) in the modulation of redox signaling and toxicity caused by xenobiotic electrophiles. | |||||||||||
書誌情報 |
en : Toxicological Research 巻 35, 号 4, p. 303-310, 発行日 2019-10 |
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ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 1976-8257 | |||||||||||
PubMed番号 | ||||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 31636841 | |||||||||||
DOI | ||||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.5487/TR.2019.35.4.303 | |||||||||||
権利 | ||||||||||||
権利情報 | This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||
著者版フラグ | ||||||||||||
値 | publisher | |||||||||||
出版者 | ||||||||||||
出版者 | Korean Society of Toxicology |