{"created":"2021-03-01T07:35:07.917469+00:00","id":54316,"links":{},"metadata":{"_buckets":{"deposit":"a5015ef8-527e-4dcd-be8b-08f305ba377e"},"_deposit":{"id":"54316","owners":[],"pid":{"revision_id":0,"type":"depid","value":"54316"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00054316","sets":["2780:551","2780:7422","3:62:5602:7898"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"310","bibliographicPageStart":"303","bibliographicVolumeNumber":"35","bibliographic_titles":[{},{"bibliographic_title":"Toxicological Research","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We are exposed to numerous xenobiotic electrophiles on a daily basis through the environment, lifestyle, and dietary habits. Although such reactive species have been associated with detrimental effects, recent accumulated evidence indicates that xenobiotic electrophiles appear to act as signaling molecules. In this review, we introduce our findings on 1) activation of various redox signaling pathways involved in cell proliferation, detoxification/excretion of electrophiles, quality control of cellular proteins, and cell survival during exposure to xenobiotic electrophiles at low concentrations through covalent modification of thiol groups in sensor proteins, and 2) negative regulation of reactive sulfur species (RSS) in the modulation of redox signaling and toxicity caused by xenobiotic electrophiles.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Korean Society of Toxicology"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31636841","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.5487/TR.2019.35.4.303","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1976-8257","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"熊谷, 嘉人"},{"creatorName":"クマガイ, ヨシト","creatorNameLang":"ja-Kana"},{"creatorName":"KUMAGAI, Yoshito","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"秋山, 雅博"},{"creatorName":"アキヤマ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"AKIYAMA, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Unoki, Takamitsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-17"}],"displaytype":"detail","filename":"TR_35-4.pdf","filesize":[{"value":"585.4 kB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"TR_35-4","url":"https://tsukuba.repo.nii.ac.jp/record/54316/files/TR_35-4.pdf"},"version_id":"ad2db3ce-b5e3-4895-9f02-1575f5001f10"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["7422","551","7898"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-17"},"publish_date":"2020-03-17","publish_status":"0","recid":"54316","relation_version_is_last":true,"title":["Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:28:38.677639+00:00"}