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Of the participants, 62 consented to the 5-year follow-up measurement session. Of these women, 47 women who achieved a weight loss of at least 10% from their baseline values during the 14-week intervention were included in the analysis. Body weight, body fat, abdominal fat assessed by CT scans, and metabolic risk factors (i.e., blood pressure, lipids, and glucose) were measured at baseline, post-intervention, and at the 5-year follow-up.\n\nResults\nDuring the 5-year non-intervention period, increases in body weight, fat mass, total abdominal fat, and subcutaneous abdominal fat were significantly greater in subjects with the homozygous minor allele (AA genotype, n = 4; 8.5%) than in those with the homozygous major allele (TT genotype, n = 31; 66.0%) or heterozygous allele (TA genotype, n = 12; 25.5%). In multiple regression analyses, the variation in rs9939609 was a significant and independent predictor (P \u003c 0.001) for regaining weight during the 5-year follow-up.\n\nConclusions\nOur data suggest that Japanese women with the risk allele (AA) of rs9939609 may have more difficulty preventing fat gain from reoccurring after weight loss intervention than women with the other genotypes.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Inc."}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "24798613", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.metabol.2014.03.013", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2014 Elsevier Inc. 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The FTO genotype as a useful predictor of body weight maintenance: Initial data from a 5-year follow-up study
http://hdl.handle.net/2241/00121918
http://hdl.handle.net/2241/001219188f0b1a8c-64ee-4fda-8e8f-4bb08720e71d
名前 / ファイル | ライセンス | アクション |
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MCAE_63-7 (176.5 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2014-08-06 | |||||
タイトル | ||||||
タイトル | The FTO genotype as a useful predictor of body weight maintenance: Initial data from a 5-year follow-up study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Matsuo, Tomoaki
× Matsuo, Tomoaki× Nakata, Yoshio× Hotta, Kikuko× Tanaka, Kiyoji |
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著者別名 |
中田, 由夫
× 中田, 由夫× 田中, 喜代次 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective We examined associations between the fat-mass and obesity-associated (FTO) gene (rs9939609) and any weight change over a 5-year period following a 14-week lifestyle intervention among middle-aged Japanese women. Materials/Methods One hundred twenty-eight Japanese women (BMI > 25 kg/m2) participated in a 14-week weight loss intervention between 2004 and 2006. Of the participants, 62 consented to the 5-year follow-up measurement session. Of these women, 47 women who achieved a weight loss of at least 10% from their baseline values during the 14-week intervention were included in the analysis. Body weight, body fat, abdominal fat assessed by CT scans, and metabolic risk factors (i.e., blood pressure, lipids, and glucose) were measured at baseline, post-intervention, and at the 5-year follow-up. Results During the 5-year non-intervention period, increases in body weight, fat mass, total abdominal fat, and subcutaneous abdominal fat were significantly greater in subjects with the homozygous minor allele (AA genotype, n = 4; 8.5%) than in those with the homozygous major allele (TT genotype, n = 31; 66.0%) or heterozygous allele (TA genotype, n = 12; 25.5%). In multiple regression analyses, the variation in rs9939609 was a significant and independent predictor (P < 0.001) for regaining weight during the 5-year follow-up. Conclusions Our data suggest that Japanese women with the risk allele (AA) of rs9939609 may have more difficulty preventing fat gain from reoccurring after weight loss intervention than women with the other genotypes. |
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書誌情報 |
Metabolism : clinical and experimental 巻 63, 号 7, p. 912-917, 発行日 2014-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0026-0495 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA0073583X | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 24798613 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.metabol.2014.03.013 | |||||
権利 | ||||||
権利情報 | © 2014 Elsevier Inc. NOTICE: this is the author’s version of a work that was accepted for publication in Metabolism : clinical and experimental. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Metabolism : clinical and experimental, 63, 7, 2014 DOI: 10.1016/j.metabol.2014.03.013 | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier Inc. |