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Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.
http://hdl.handle.net/2241/102296
http://hdl.handle.net/2241/102296192e50b4-157d-4588-b007-f115683ac4e4
名前 / ファイル | ライセンス | アクション |
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JCI_101-8.pdf (157.3 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2009-04-24 | |||||
タイトル | ||||||
タイトル | Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Abe, Hideki
× Abe, Hideki× 山田, 信博× Kamata, Katsuo× Kuwaki, Tomoyuki× Shimada, Masako× Osuga, Junichi× Shionoiri, Futoshi× Yahagi, Naoya× Kadowaki, Takashi× Tamemoto, Hiroyuki× Ishibashi, Shun× Yazaki, Yoshio× Makuuchi, Masatoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Insulin resistance is often associated with atherosclerotic diseases in subjects with obesity and impaired glucose tolerance. This study examined the effects of insulin resistance on coronary risk factors in IRS-1 deficient mice, a nonobese animal model of insulin resistance. Blood pressure and plasma triglyceride levels were significantly higher in IRS-1 deficient mice than in normal mice. Impaired endothelium-dependent vascular relaxation was also observed in IRS-1 deficient mice. Furthermore, lipoprotein lipase activity was lower than in normal mice, suggesting impaired lipolysis to be involved in the increase in plasma triglyceride levels under insulin-resistant conditions. Thus, insulin resistance plays an important role in the clustering of coronary risk factors which may accelerate the progression of atherosclerosis in subjects with insulin resistance. | |||||
言語 | en | |||||
書誌情報 |
en : The journal of clinical investigation 巻 101, 号 8, p. 1784-1788, 発行日 1998-04 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0021-9738 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1172/JCI1594 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 9541510 | |||||
権利情報 | ||||||
言語 | en | |||||
権利情報 | © The American Society for Clinical Investigation | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | The American Society for Clinical Investigation | |||||
言語 | en |