@article{oai:tsukuba.repo.nii.ac.jp:00017609,
 author = {Abe, Hideki and 山田, 信博 and YAMADA, Nobuhiro and Kamata, Katsuo and Kuwaki, Tomoyuki and Shimada, Masako and Osuga, Junichi and Shionoiri, Futoshi and Yahagi, Naoya and Kadowaki, Takashi and Tamemoto, Hiroyuki and Ishibashi, Shun and Yazaki, Yoshio and Makuuchi, Masatoshi},
 issue = {8},
 journal = {The journal of clinical investigation},
 month = {Apr},
 note = {Insulin resistance is often associated with atherosclerotic diseases in subjects with obesity and impaired glucose tolerance. This study examined the effects of insulin resistance on coronary risk factors in IRS-1 deficient mice, a nonobese animal model of insulin resistance. Blood pressure and plasma triglyceride levels were significantly higher in IRS-1 deficient mice than in normal mice. Impaired endothelium-dependent vascular relaxation was also observed in IRS-1 deficient mice. Furthermore, lipoprotein lipase activity was lower than in normal mice, suggesting impaired lipolysis to be involved in the increase in plasma triglyceride levels under insulin-resistant conditions. Thus, insulin resistance plays an important role in the clustering of coronary risk factors which may accelerate the progression of atherosclerosis in subjects with insulin resistance.},
 pages = {1784--1788},
 title = {Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.},
 volume = {101},
 year = {1998},
 yomi = {ヤマダ, ノブヒロ}
}