@phdthesis{oai:tsukuba.repo.nii.ac.jp:00009112, author = {Chieri, Tomomori-Sato and 佐藤, チエリ}, month = {}, note = {To survive, bacteria monitor and adapt to changes in their growth envirooment (toxic chemicals, nitrate starvation, osmolarity, nutrition, etc.) through a family of signal transduction proteins, namely sensor kinases and their cognate response regulators. the former are histidine kinases that sense some environmental parameter and the latter mediate changes in gene expression or cell behavior. This so-called two component system is unique in transferrig the signal by the reversible phosphorelay of a phosphate between the histidine residue of a sensor kinase and the aspartic acid residue in a response regulator. In addition to the classic two component system which orginated in 1986 (Nixon et al., 1986), systems have been identified in multi-component pathway such as seven components involving chemotaxis pathway, ..., 1999}, school = {筑波大学, University of Tsukuba}, title = {Structural studies on the osmosensor EnvZ by NMR spectroscopy}, year = {1999} }