{"created":"2021-03-01T06:44:38.397740+00:00","id":9110,"links":{},"metadata":{"_buckets":{"deposit":"bf4431c9-c70b-4a41-a737-51d67cc5c965"},"_deposit":{"id":"9110","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9110"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00009110","sets":["3:233:243"]},"author_link":["36882"],"control_number":"9110","item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992","bibliographicIssueDateType":"Issued"}}]},"item_12_date_granted_46":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1992-03-25"}]},"item_12_degree_grantor_44":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"筑波大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"University of Tsukuba"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"12102","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_43":{"attribute_name":"取得学位","attribute_value_mlt":[{"subitem_degreename":"博士（学術）","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy","subitem_degreename_language":"en"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human angiotensinogen, a glycoprotein consisting of 452 amino acids (1,2), is synthesized predominantly in the liver and secreted into the circulation, where the enzyme renin (EC3.4.23.15) cleaves angiotensinogen to generates angiotensin I. Subsequently, angiotensin I is processed to octapeptide angiotensin II, a most potent vasoconstrictor, by angiotensin-converting enzyme. Since the cleavage of angiotensinogen by renin is thought to be the rate-limiting step in the physiological cascade, the renin-angiotensin system plays an important role in the regulation of blood pressure and thus bas been implicated in the pathogenesis of hypertension (Fig.1). ...","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_12_description_45":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"1991","subitem_description_type":"Other"}]},"item_12_dissertation_number_47":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1041号"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Shigeru","creatorNameLang":"en"},{"creatorName":"高橋, 滋","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"36882","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-18"}],"displaytype":"detail","filename":"A1041.pdf","filesize":[{"value":"356.2 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tsukuba.repo.nii.ac.jp/record/9110/files/A1041.pdf"},"version_id":"127f201b-ef72-4c20-8cb6-c672f0586998"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-18"}],"displaytype":"detail","filename":"1.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tsukuba.repo.nii.ac.jp/record/9110/files/1.pdf"},"version_id":"5bfadd6d-307c-4ae2-b859-5dfc7ac81ccf"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Structure of the human angiotensinogen gene and its regulation in cultured cells and transgenic mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structure of the human angiotensinogen gene and its regulation in cultured cells and transgenic mice","subitem_title_language":"en"}]},"item_type_id":"12","owner":"1","path":["243"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-07-25"},"publish_date":"2007-07-25","publish_status":"0","recid":"9110","relation_version_is_last":true,"title":["Structure of the human angiotensinogen gene and its regulation in cultured cells and transgenic mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-04-17T00:07:39.111910+00:00"}