{"created":"2021-03-01T06:44:37.662411+00:00","id":9100,"links":{},"metadata":{"_buckets":{"deposit":"92270e8f-6737-4f54-9e17-bee9fde07129"},"_deposit":{"created_by":221,"id":"9100","owners":[221],"pid":{"revision_id":0,"type":"depid","value":"9100"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00009100","sets":["3:233:243"]},"author_link":["36857"],"item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996","bibliographicIssueDateType":"Issued"}}]},"item_12_date_granted_46":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1996-03-25"}]},"item_12_degree_grantor_44":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"筑波大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"University of Tsukuba"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"12102","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_43":{"attribute_name":"取得学位","attribute_value_mlt":[{"subitem_degreename":"博士（学術）"},{"subitem_degreename":"Doctor of Philosophy"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Angiotensin II(Ang II), a biologically active peptide in the reninangiotensin system \n(RAS), plays an important role in the maintenance of blood pressure and fluid osmolarity[1,2,3]. In addition, Ang II promotes growth responses in many cells, including cardiomyocytes, cardiac fibroblasts, and vascular smooth muscle cells [1,2,3]. The RAS is activated by an enzyme cascade that consists of cleavage of angiotensinogen by renin, liberating the inactive decapeptide angiotensin I, and by the action of angiotensin-converting enzyme, which converts angiotensin I into the active effector hormone of hte system, Ang II. The Physiological effects of Ang II are elicited through binding to its specific cell-surface receptors present in target tissues and organs. ...","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_12_description_45":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"1995","subitem_description_type":"Other"}]},"item_12_dissertation_number_47":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1489号"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shibata, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"36857","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-18"}],"displaytype":"detail","filename":"A1489.pdf","filesize":[{"value":"175.8 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tsukuba.repo.nii.ac.jp/record/9100/files/A1489.pdf"},"version_id":"8695377f-06fc-4dae-9540-5308c77f3b14"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Studies on the structure-function relationship of angiotensin II type 1 receptor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Studies on the structure-function relationship of angiotensin II type 1 receptor","subitem_title_language":"en"}]},"item_type_id":"12","owner":"221","path":["243"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-07-25"},"publish_date":"2007-07-25","publish_status":"0","recid":"9100","relation_version_is_last":true,"title":["Studies on the structure-function relationship of angiotensin II type 1 receptor"],"weko_creator_id":"221","weko_shared_id":-1},"updated":"2024-02-07T23:51:50.305828+00:00"}