@phdthesis{oai:tsukuba.repo.nii.ac.jp:00009100, author = {Shibata, Takeshi}, month = {}, note = {Angiotensin II(Ang II), a biologically active peptide in the reninangiotensin system (RAS), plays an important role in the maintenance of blood pressure and fluid osmolarity[1,2,3]. In addition, Ang II promotes growth responses in many cells, including cardiomyocytes, cardiac fibroblasts, and vascular smooth muscle cells [1,2,3]. The RAS is activated by an enzyme cascade that consists of cleavage of angiotensinogen by renin, liberating the inactive decapeptide angiotensin I, and by the action of angiotensin-converting enzyme, which converts angiotensin I into the active effector hormone of hte system, Ang II. The Physiological effects of Ang II are elicited through binding to its specific cell-surface receptors present in target tissues and organs. ..., 1995}, school = {筑波大学, University of Tsukuba}, title = {Studies on the structure-function relationship of angiotensin II type 1 receptor}, year = {1996} }