{"created":"2021-03-01T06:44:26.562374+00:00","id":8943,"links":{},"metadata":{"_buckets":{"deposit":"4bb5ea84-7ab7-48e4-afe0-c4e5fd09ae2e"},"_deposit":{"id":"8943","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8943"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00008943","sets":["3:233:239"]},"author_link":["36390"],"control_number":"8943","item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001","bibliographicIssueDateType":"Issued"}}]},"item_12_date_granted_46":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2001-03-23"}]},"item_12_degree_grantor_44":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"筑波大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"University of Tsukuba"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"12102","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_43":{"attribute_name":"取得学位","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"},{"subitem_degreename":"Doctor of Philosophy in Medical Sciences"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Pulmonary hypertension (PH) is a poor prognostic and drug-resistant disease. Recently, it has been reported that continuous intravenous prostacyclin (PGI2) administration is effectual for PH; however, its effect is not sufficient to treat PH. We previously reported that chronic treatment with an endothelin (ET)-A receptor antagonist was effective for PH in rats. In this study, we investigated whether the combination on an oral ET-A receptor antagonist and an oral PGI2 analogue is superior to the single use of each drug alone for treating PH. Methods and Results ...","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_12_description_45":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2000","subitem_description_type":"Other"}]},"item_12_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Includes bibliographical references","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Includes supplementary treatises","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_12_dissertation_number_47":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2663号"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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