{"created":"2021-03-01T06:44:22.360875+00:00","id":8884,"links":{},"metadata":{"_buckets":{"deposit":"bb22be7d-a21f-472f-b06e-8b4b441dee47"},"_deposit":{"id":"8884","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8884"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00008884","sets":["3:233:239"]},"author_link":["36208"],"control_number":"8884","item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000","bibliographicIssueDateType":"Issued"}}]},"item_12_date_granted_46":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2000-03-24"}]},"item_12_degree_grantor_44":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"筑波大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"University of Tsukuba"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"12102","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_43":{"attribute_name":"取得学位","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"},{"subitem_degreename":"Doctor of Philosophy in Medical Sciences"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Evidence is mounting that endothelin(ET)-1 has proatherogenic properties.This is supported by finding that selective ETA receptor antagonists reduce atherosclerotic immunoreactivity of ET-1 and ETB receptors in human and mouse atherosclerotic lesions.To examine additional effects of ETB receptor antaagonism on atherogenesis,we investigated the choronic effect of the nonselecive ETA/ETB receptor antagonist SB209670 on the development of atherosclerosis in apolipoprotein E(apoE)-deficient mice.94 male mice(10weeks of age)were randomly divided into four groups:Mice fed a Western-type diet or a chow diet with SB209670 treatment(10mg/kg/day)or placebo for 12 weeks.In mice fed the Western-diet,but not in mice fed the chow diet, treatment with SB209670 signigicantly attenuated the increase of plasma total cholesterol level predominantly in very low density lipoprotein and ...","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_12_description_45":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"1999","subitem_description_type":"Other"}]},"item_12_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Includes supplementary treatises","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Includes bibliographical references","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_12_dissertation_number_47":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2375号"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩佐, 敏","creatorNameLang":"ja"},{"creatorName":"Iwasa, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"36208","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-18"}],"displaytype":"detail","filename":"A2375.pdf","filesize":[{"value":"160.5 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ET-1 effect through the ET[B] receptor plays an important role in atherogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Non-selective endothelin receptor antagonist reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein edeficient mice. ET-1 effect through the ET[B] receptor plays an important role in atherogenesis","subitem_title_language":"en"},{"subitem_title":"非選択的エンドセリン受容体拮抗薬は、アポE欠損マウスの食餌性高コレステロール血症と動脈硬化病変を抑制する。動脈硬化発生におけるエンドセリンB受容体を介したET-1作用の重要性について","subitem_title_language":"ja"}]},"item_type_id":"12","owner":"1","path":["239"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-07-25"},"publish_date":"2007-07-25","publish_status":"0","recid":"8884","relation_version_is_last":true,"title":["Non-selective endothelin receptor antagonist reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein edeficient mice. ET-1 effect through the ET[B] receptor plays an important role in atherogenesis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-04-26T04:40:16.611791+00:00"}