@phdthesis{oai:tsukuba.repo.nii.ac.jp:00008884, author = {岩佐, 敏 and Iwasa, Satoshi}, month = {}, note = {Evidence is mounting that endothelin(ET)-1 has proatherogenic properties.This is supported by finding that selective ETA receptor antagonists reduce atherosclerotic immunoreactivity of ET-1 and ETB receptors in human and mouse atherosclerotic lesions.To examine additional effects of ETB receptor antaagonism on atherogenesis,we investigated the choronic effect of the nonselecive ETA/ETB receptor antagonist SB209670 on the development of atherosclerosis in apolipoprotein E(apoE)-deficient mice.94 male mice(10weeks of age)were randomly divided into four groups:Mice fed a Western-type diet or a chow diet with SB209670 treatment(10mg/kg/day)or placebo for 12 weeks.In mice fed the Western-diet,but not in mice fed the chow diet, treatment with SB209670 signigicantly attenuated the increase of plasma total cholesterol level predominantly in very low density lipoprotein and ..., 1999, Includes supplementary treatises, Includes bibliographical references}, school = {筑波大学, University of Tsukuba}, title = {Non-selective endothelin receptor antagonist reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein edeficient mice. ET-1 effect through the ET[B] receptor plays an important role in atherogenesis}, year = {2000} }