{"created":"2021-03-01T06:44:20.531344+00:00","id":8858,"links":{},"metadata":{"_buckets":{"deposit":"9e11e31e-13ce-4521-838d-363f9224a3e0"},"_deposit":{"id":"8858","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8858"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00008858","sets":["3:233:239"]},"author_link":["36131"],"item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988","bibliographicIssueDateType":"Issued"}}]},"item_12_date_granted_46":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1988-03-25"}]},"item_12_degree_grantor_44":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"筑波大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"University of Tsukuba"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"12102","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_43":{"attribute_name":"取得学位","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"},{"subitem_degreename":"Doctor of Philosophy in Medical Sciences"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ビトロネクチンは、血漿中や組織中に存在する糖蛋白質でフィブロネクチンなどと共に細胞接着性蛋白質と呼ばれる。細胞接着性蛋白質は、培養皿（プラスチックなど）や細胞外マトリックス(コラーゲン、グリコサミノグリカンなど)と細胞とを橋渡しして両者を接着させる活性をもつ蛋白質の総称である。細胞接着性蛋白質は、細胞膜に組み込まれた蛋白質ではなく、細胞外に存在して細胞膜上のレセプターに結合する。そして、この結合により細胞の形態や機能に影響を及ぼす。細胞接着蛋白質の中で最も研究が進んでいるのが、フィブロネクチン(fibronectin)である。フィブロネクチンは、細胞接着や細胞伸展の促進、細胞移動の促進、食作用の促進、細胞増殖の促進、細胞分化の調節、組織修復の促進、などの多彩な生物学的活性を持つ蛋白質である。このため多くの分野でフィブロネクチンに対する関心が持たれ、研究が進んだ。その結果、細胞接着性蛋白質の存在とその役割の重要性に対する認識が増し、他の細胞接着性蛋白質の研究も行われるようになった。ビトロネクチン(vitronectin)は、フィブロネクチンとは別の細胞接着性蛋白質として、1983年以降本格的に研究が進んだ。本論文では、ビトロネクチンの研究の歴史に触れた後、筆者が1984年から取り組んだ構造と機能に関する研究に関して文献的考察を加えて述べていく。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_12_description_45":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"1987","subitem_description_type":"Other"}]},"item_12_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"付:参考論文","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_12_dissertation_number_47":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第571号"}]},"item_12_relation_37":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"全文はOPACにあり"}],"subitem_relation_type":"hasFormat","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.tulips.tsukuba.ac.jp/opac/volume/337483","subitem_relation_type_select":"URI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"赤間, 高雄","creatorNameLang":"ja"},{"creatorName":"Akama, Takao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"36131","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-18"}],"displaytype":"detail","filename":"A0571.pdf","filesize":[{"value":"123.5 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tsukuba.repo.nii.ac.jp/record/8858/files/A0571.pdf"},"version_id":"b6da361f-148e-42f7-9102-66e2b76391f7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"ビトロネクチンの構造と機能に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ビトロネクチンの構造と機能に関する研究","subitem_title_language":"ja"}]},"item_type_id":"12","owner":"1","path":["239"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-07-25"},"publish_date":"2007-07-25","publish_status":"0","recid":"8858","relation_version_is_last":true,"title":["ビトロネクチンの構造と機能に関する研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-04-26T04:37:53.957711+00:00"}