{"created":"2021-03-01T06:43:44.873843+00:00","id":8357,"links":{},"metadata":{"_buckets":{"deposit":"315008e6-a24a-42b9-abc2-40658b36521f"},"_deposit":{"id":"8357","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8357"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00008357","sets":["3:233:254"]},"author_link":["34778"],"item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004","bibliographicIssueDateType":"Issued"}}]},"item_12_date_granted_46":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2004-03-25"}]},"item_12_degree_grantor_44":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"筑波大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"University of Tsukuba"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"12102","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_43":{"attribute_name":"取得学位","attribute_value_mlt":[{"subitem_degreename":"博士（理学）"},{"subitem_degreename":"Doctor of Philosophy in Science"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Molecular mechanisms of cephalic development is an intriguing question in evolutionary and developmental biology. Otx gene plays important roles in animal brain and head development and Otx genes are found in all major animal groups: cnidarians, lophotrochozoans, ecdysozoans, and\ndeuterostomes. Ascidians, positioned near the origin of the phylum Chordata, share a conserved set of anteroposterior patterning genes with\nthat of vertebrates. Here I report the cross-phylum regulatory potential of the ascidian Otx gene in the development of the Drosophila brain and the head vertex structures. The ascidian Otx gene rescued the embryonic brain defect of Drosophila caused by null mutation of the orthodenticle (otd) gene and enhanced rostral brain development while it suppressed trunk\nnerve cord formation. Furthermore, the ascidian Otx gene restored the head vertex defects caused by a viable otd mutation, ocelliless, via specific\nactivation and repression of downstream regulatory genes. The crossphylum regulatory potentials of the ascidian Otx gene are equivalent to the activities of the Drosophila and human otd/Otx genes in these developmental processes. In contrast to these results, cnidarian Otx gene showed little functional equivalence in Drosophila. In addition, planarian\nOtx gene had failed to rescue Drosophila embryonic brain development. The results with ascidian Otx gene function support the notion that\nbasal chordates such as ascidians have the similar molecular patterningmechanism for the anterior structures found in higher chordates, and\nsuggest a common genetic program of cephalic development among invertebrate, protochordate and vertebrate.  ･･･","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_12_description_45":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2003","subitem_description_type":"Other"}]},"item_12_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Includes bibliographical references","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_12_dissertation_number_47":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3328号"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安達, 在嗣","creatorNameLang":"ja"},{"creatorName":"Adachi, Yoshitsugu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34778","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2013-12-18"}],"displaytype":"detail","filename":"A3328.pdf","filesize":[{"value":"161.4 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tsukuba.repo.nii.ac.jp/record/8357/files/A3328.pdf"},"version_id":"faa5aace-04bf-4820-9246-be6717a3d5b4"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2013-12-18"}],"displaytype":"detail","filename":"1.pdf","filesize":[{"value":"786.3 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tsukuba.repo.nii.ac.jp/record/8357/files/1.pdf"},"version_id":"7f108425-2cd0-4302-bf44-6f8862250f9d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Cross-phylum functional equivalence of Otx genes and the origin of brain patterning","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cross-phylum functional equivalence of Otx genes and the origin of brain patterning","subitem_title_language":"en"}]},"item_type_id":"12","owner":"1","path":["254"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-07-25"},"publish_date":"2007-07-25","publish_status":"0","recid":"8357","relation_version_is_last":true,"title":["Cross-phylum functional equivalence of Otx genes and the origin of brain patterning"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-02T01:13:15.431973+00:00"}