{"created":"2021-03-01T07:37:01.847795+00:00","id":55980,"links":{},"metadata":{"_buckets":{"deposit":"40457188-a50b-470e-8973-7a78139f5fcd"},"_deposit":{"id":"55980","owners":[],"pid":{"revision_id":0,"type":"depid","value":"55980"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00055980","sets":["2780:8108","3:62:5600:7225"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"100","bibliographicPageStart":"95","bibliographicVolumeNumber":"11","bibliographic_titles":[{},{"bibliographic_title":"Regenerative Therapy","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cardiovascular disease is the leading cause of death globally. Cardiomyocytes (CMs) have poor regenerative capacity, and pharmacological therapies have limited efficacy in severe heart failure. Currently, there are several promising strategies for cardiac regeneration. The most promising approach to remuscularize failing hearts is cell transplantation therapy using newly generated CMs from exogenous sources, such as pluripotent stem cells. Alternatively, approaches to generate new CMs from endogenous cell sources in situ may also repair the injured heart and improve cardiac function. Direct cardiac reprogramming has emerged as a novel therapeutic approach to regenerate injured hearts by directly converting endogenous cardiac fibroblasts into CM-like cells. Through cell transplantation and direct cardiac reprogramming, new CMs can be generated and scar tissue reduced to improve cardiac function; therefore, cardiac regeneration may serve as a powerful strategy for treatment of severe heart failure. While substantial progress has been made in these two strategies for cardiac regeneration over the past several years, challenges remain for clinical translation. This review provide an overview of previous reports and current challenges in this field.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31304202","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.reth.2019.06.004","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"23523204","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"貞廣, 威太郎"},{"creatorName":"サダヒロ, タケタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"SADAHIRO, Taketaro","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-17"}],"displaytype":"detail","filename":"RT_11.pdf","filesize":[{"value":"486.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"RT_11","url":"https://tsukuba.repo.nii.ac.jp/record/55980/files/RT_11.pdf"},"version_id":"b0c6a53b-0eee-42f0-b38d-fd7b0d547e5e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cardiac regeneration with pluripotent stem cell-derived cardiomyocytes and direct cardiac reprogramming","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cardiac regeneration with pluripotent stem cell-derived cardiomyocytes and direct cardiac reprogramming","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["8108","7225"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-17"},"publish_date":"2020-09-17","publish_status":"0","recid":"55980","relation_version_is_last":true,"title":["Cardiac regeneration with pluripotent stem cell-derived cardiomyocytes and direct cardiac reprogramming"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:31:00.296040+00:00"}