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Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight
http://hdl.handle.net/2241/00161177
0b57ddd5-4200-4434-a303-f6807a01e76c
名前 / ファイル | ライセンス | Actions | |
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item type | Journal Article(1) | |||||||||||
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公開日 | 2020-09-04 | |||||||||||
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言語 | en | |||||||||||
タイトル | Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
タイプ | journal article | |||||||||||
著者 |
工藤, 崇
× 工藤, 崇× 濱田, 理人× 全, 孝静× 村谷, 匡史
WEKO
204931
× 高橋, 智× Horie, Kenta× Kato, Tamotsu× Sasanuma, Hiroki× Miyauchi, Maki× Akiyama, Nobuko× Miyao, Takahisa× Seki, Takao× Ishikawa, Tatsuya× Takakura, Yuki× Shirakawa, Masaki× Shiba, Dai× Yoshida, Nobuaki× Inoue, Jun-ichiro× Ohno, Hiroshi× Akiyama, Taishin |
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抄録 | ||||||||||||
内容記述 | The environment experienced during spaceflight may impact the immune system and the thymus appears to undergo atrophy during spaceflight. However, molecular aspects of this thymic atrophy remain to be elucidated. In this study, we analysed the thymi of mice on board the international space station (ISS) for approximately 1 month. Thymic size was significantly reduced after spaceflight. Notably, exposure of mice to 1 × g using centrifugation cages in the ISS significantly mitigated the reduction in thymic size. Although spaceflight caused thymic atrophy, the global thymic structure was not largely changed. However, RNA sequencing analysis of the thymus showed significantly reduced expression of cell cycle-regulating genes in two independent spaceflight samples. These reductions were partially countered by 1 × g exposure during the space flights. Thus, our data suggest that spaceflight leads to reduced proliferation of thymic cells, thereby reducing the size of the thymus, and exposure to 1 × g might alleviate the impairment of thymus homeostasis induced by spaceflight. | |||||||||||
書誌情報 |
en : Scientific Reports 巻 9, p. 19866, 発行日 2019-12 |
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収録物識別子 | 2045-2322 | |||||||||||
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関連識別子 | 31882694 | |||||||||||
DOI | ||||||||||||
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関連識別子 | 10.1038/s41598-019-56432-9 | |||||||||||
権利 | ||||||||||||
権利情報 | © The Author(s) 2019 | |||||||||||
権利 | ||||||||||||
権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |||||||||||
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値 | publisher | |||||||||||
出版者 | ||||||||||||
出版者 | Nature |