{"_buckets": {"deposit": "d3d93f76-a248-49a6-8c79-8ff04ad077e9"}, "_deposit": {"id": "55773", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "55773"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00055773"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-12", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "19866", "bibliographicVolumeNumber": "9", "bibliographic_titles": [{}, {"bibliographic_title": "Scientific Reports", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The environment experienced during spaceflight may impact the immune system and the thymus appears to undergo atrophy during spaceflight. However, molecular aspects of this thymic atrophy remain to be elucidated. In this study, we analysed the thymi of mice on board the international space station (ISS) for approximately 1 month. Thymic size was significantly reduced after spaceflight. Notably, exposure of mice to 1\u2009\u00d7\u2009g using centrifugation cages in the ISS significantly mitigated the reduction in thymic size. Although spaceflight caused thymic atrophy, the global thymic structure was not largely changed. However, RNA sequencing analysis of the thymus showed significantly reduced expression of cell cycle-regulating genes in two independent spaceflight samples. These reductions were partially countered by 1\u2009\u00d7\u2009g exposure during the space flights. Thus, our data suggest that spaceflight leads to reduced proliferation of thymic cells, thereby reducing the size of the thymus, and exposure to 1\u2009\u00d7\u2009g might alleviate the impairment of thymus homeostasis induced by spaceflight.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nature"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "31882694", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/s41598-019-56432-9", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 The Author(s) 2019"}, {"subitem_rights": "This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article\u2019s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article\u2019s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/."}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5de5\u85e4, \u5d07"}, {"creatorName": "\u30af\u30c9\u30a6, \u30bf\u30ab\u30b7", "creatorNameLang": "ja-Kana"}, {"creatorName": "KUDO, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "115", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20288062", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000020288062"}, {"nameIdentifier": "0000001617", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001617"}]}, {"creatorNames": [{"creatorName": "\u6ff1\u7530, \u7406\u4eba"}, {"creatorName": "\u30cf\u30de\u30c0, \u30df\u30c1\u30c8", "creatorNameLang": "ja-Kana"}, {"creatorName": "HAMADA, Michito", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "204681", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20567630", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000020567630"}, {"nameIdentifier": "0000002372", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000002372"}]}, {"creatorNames": [{"creatorName": "\u5168, \u5b5d\u9759"}, {"creatorName": "\u30b8\u30e7\u30f3, \u30d2\u30e7\u30b8\u30e7\u30f3", "creatorNameLang": "ja-Kana"}, {"creatorName": "JEON, Hyojung", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "218730", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "0000004353", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000004353"}]}, {"creatorNames": [{"creatorName": "\u6751\u8c37, \u5321\u53f2"}, {"creatorName": "\u30e0\u30e9\u30bf\u30cb, \u30de\u30b5\u30d5\u30df", "creatorNameLang": "ja-Kana"}, {"creatorName": "MURATANI, Masafumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "204931", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50730199", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000050730199"}, {"nameIdentifier": "0000003520", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000003520"}]}, {"creatorNames": [{"creatorName": "\u9ad8\u6a4b, \u667a"}, {"creatorName": "\u30bf\u30ab\u30cf\u30b7, \u30b5\u30c8\u30eb", "creatorNameLang": "ja-Kana"}, {"creatorName": "TAKAHASHI, Satoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "171", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50271896", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000050271896"}, {"nameIdentifier": "0000001614", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001614"}]}, {"creatorNames": [{"creatorName": "Horie, Kenta", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221940", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Tamotsu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221941", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasanuma, Hiroki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221942", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyauchi, Maki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221943", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akiyama, Nobuko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221944", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyao, Takahisa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221945", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Seki, Takao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221946", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Tatsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221947", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takakura, Yuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221948", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shirakawa, Masaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221949", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shiba, Dai", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221950", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, Nobuaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221951", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoue, Jun-ichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221952", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohno, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221953", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akiyama, Taishin", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "221954", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-09-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "SR_9-19866.pdf", "filesize": [{"value": "4.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 4400000.0, "url": {"label": "SR_9-19866", "url": "https://tsukuba.repo.nii.ac.jp/record/55773/files/SR_9-19866.pdf"}, "version_id": "2005a6fe-e9c1-4b20-a41a-cbcb21da641a"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["2780/542", "2780/7938", "2780/544", "2780/5369", "2780/5713", "3/62/5601/1884"], "permalink_uri": "http://hdl.handle.net/2241/00161177", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2020-09-04"}, "publish_date": "2020-09-04", "publish_status": "0", "recid": "55773", "relation": {}, "relation_version_is_last": true, "title": ["Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight"], "weko_shared_id": 5}