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  1. 医学医療系 (Faculty of Medicine)
  2. 濱田 理人 (Hamada Michito)
  1. 医学医療系 (Faculty of Medicine)
  2. 工藤 崇 (Kudo Takashi)
  1. 医学医療系 (Faculty of Medicine)
  2. 高橋 智 (Takahashi Satoru)
  1. 医学医療系 (Faculty of Medicine)
  2. 村谷 匡史 (Muratani Masafumi)
  1. 医学医療系 (Faculty of Medicine)
  2. 全 孝静 (Jeon Hyojung)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. S~
  4. Scientific reports

Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight

http://hdl.handle.net/2241/00161177
0b57ddd5-4200-4434-a303-f6807a01e76c
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SR_9-19866.pdf SR_9-19866 (4.4 MB)
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item type Journal Article(1)
公開日 2020-09-04
タイトル
言語 en
タイトル Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight
言語
言語 eng
資源タイプ
タイプ journal article
著者 工藤, 崇

× 工藤, 崇

WEKO 115
e-Rad 20288062
筑波大学研究者総覧 0000001617

工藤, 崇

ja-Kana クドウ, タカシ

en KUDO, Takashi

Search repository
濱田, 理人

× 濱田, 理人

WEKO 204681
e-Rad 20567630
筑波大学研究者総覧 0000002372

濱田, 理人

ja-Kana ハマダ, ミチト

en HAMADA, Michito

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全, 孝静

× 全, 孝静

WEKO 218730
筑波大学研究者総覧 0000004353

全, 孝静

ja-Kana ジョン, ヒョジョン

en JEON, Hyojung

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村谷, 匡史

× 村谷, 匡史

WEKO 204931
e-Rad 50730199
筑波大学研究者総覧 0000003520

村谷, 匡史

ja-Kana ムラタニ, マサフミ

en MURATANI, Masafumi

Search repository
高橋, 智

× 高橋, 智

WEKO 171
e-Rad 50271896
筑波大学研究者総覧 0000001614

高橋, 智

ja-Kana タカハシ, サトル

en TAKAHASHI, Satoru

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Horie, Kenta

× Horie, Kenta

WEKO 221940

en Horie, Kenta

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Kato, Tamotsu

× Kato, Tamotsu

WEKO 221941

en Kato, Tamotsu

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Sasanuma, Hiroki

× Sasanuma, Hiroki

WEKO 221942

en Sasanuma, Hiroki

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Miyauchi, Maki

× Miyauchi, Maki

WEKO 221943

en Miyauchi, Maki

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Akiyama, Nobuko

× Akiyama, Nobuko

WEKO 221944

en Akiyama, Nobuko

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Miyao, Takahisa

× Miyao, Takahisa

WEKO 221945

en Miyao, Takahisa

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Seki, Takao

× Seki, Takao

WEKO 221946

en Seki, Takao

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Ishikawa, Tatsuya

× Ishikawa, Tatsuya

WEKO 221947

en Ishikawa, Tatsuya

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Takakura, Yuki

× Takakura, Yuki

WEKO 221948

en Takakura, Yuki

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Shirakawa, Masaki

× Shirakawa, Masaki

WEKO 221949

en Shirakawa, Masaki

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Shiba, Dai

× Shiba, Dai

WEKO 221950

en Shiba, Dai

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Yoshida, Nobuaki

× Yoshida, Nobuaki

WEKO 221951

en Yoshida, Nobuaki

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Inoue, Jun-ichiro

× Inoue, Jun-ichiro

WEKO 221952

en Inoue, Jun-ichiro

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Ohno, Hiroshi

× Ohno, Hiroshi

WEKO 221953

en Ohno, Hiroshi

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Akiyama, Taishin

× Akiyama, Taishin

WEKO 221954

en Akiyama, Taishin

Search repository
抄録
内容記述 The environment experienced during spaceflight may impact the immune system and the thymus appears to undergo atrophy during spaceflight. However, molecular aspects of this thymic atrophy remain to be elucidated. In this study, we analysed the thymi of mice on board the international space station (ISS) for approximately 1 month. Thymic size was significantly reduced after spaceflight. Notably, exposure of mice to 1 × g using centrifugation cages in the ISS significantly mitigated the reduction in thymic size. Although spaceflight caused thymic atrophy, the global thymic structure was not largely changed. However, RNA sequencing analysis of the thymus showed significantly reduced expression of cell cycle-regulating genes in two independent spaceflight samples. These reductions were partially countered by 1 × g exposure during the space flights. Thus, our data suggest that spaceflight leads to reduced proliferation of thymic cells, thereby reducing the size of the thymus, and exposure to 1 × g might alleviate the impairment of thymus homeostasis induced by spaceflight.
書誌情報 en : Scientific Reports

巻 9, p. 19866, 発行日 2019-12
ISSN
収録物識別子 2045-2322
PubMed番号
関連識別子
関連識別子 31882694
DOI
関連識別子
関連識別子 10.1038/s41598-019-56432-9
権利
権利情報 © The Author(s) 2019
権利
権利情報 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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出版者 Nature
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