{"created":"2021-03-01T07:36:45.822053+00:00","id":55752,"links":{},"metadata":{"_buckets":{"deposit":"f273c7d7-0b25-4a1f-a756-8dfa6b0e2bde"},"_deposit":{"id":"55752","owners":[],"pid":{"revision_id":0,"type":"depid","value":"55752"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00055752","sets":["2780:2759","2780:7233","3:62:5602:7283"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"597","bibliographicVolumeNumber":"11","bibliographic_titles":[{},{"bibliographic_title":"Toxins","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Atrial fibrillation (AF) is the most prevalent arrhythmia in the general population. There is a close association between chronic kidney disease (CKD) and AF. In recent years, attention has been focused on the relationship between AF and uremic toxins, including indoxyl sulfate (IS). Several animal studies have shown that IS promotes the development and progression of AF. IS has been shown to cause fibrosis and inflammation in the myocardium and exacerbate AF by causing oxidative stress and reducing antioxidative defense. Administration of AST-120, an absorbent of uremic toxins, decreases uremic toxin-induced AF in rodents. We have recently reported that patients with a higher serum IS level exhibit a higher rate of AF recurrence after catheter ablation, with serum IS being a significant predictor of AF recurrence. In this review, we discuss the possible mechanisms behind the AF-promoting effects of uremic toxins and summarize the reported clinical studies of uremic toxin-induced AF.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31614923","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/toxins11100597","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-6651","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田尻, 和子"},{"creatorName":"タジリ, カズコ","creatorNameLang":"ja-Kana"},{"creatorName":"TAJIRI, Kazuko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"家田, 真樹"},{"creatorName":"イエダ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"IEDA, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamagami, Fumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yumino, Dai","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-03"}],"displaytype":"detail","filename":"toxins_11-10.pdf","filesize":[{"value":"553.8 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"toxins_11-10","url":"https://tsukuba.repo.nii.ac.jp/record/55752/files/toxins_11-10.pdf"},"version_id":"e60690ff-ac5e-43d3-ae16-78761aa07317"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Uremic Toxins and Atrial Fibrillation: Mechanisms and Therapeutic Implications","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Uremic Toxins and Atrial Fibrillation: Mechanisms and Therapeutic Implications","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["7233","2759","7283"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-03"},"publish_date":"2020-09-03","publish_status":"0","recid":"55752","relation_version_is_last":true,"title":["Uremic Toxins and Atrial Fibrillation: Mechanisms and Therapeutic Implications"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:30:33.314908+00:00"}