@article{oai:tsukuba.repo.nii.ac.jp:00055722,
 author = {磯辺, 智範 and ISOBE, Tomonori and 森, 祐太郎 and MORI, Yutaro and 武居, 秀行 and TAKEI, Hideyuki and 熊田, 博明 and KUMADA, Hiroaki and 榮, 武二 and SAKAE, Takeji and Kobayashi, Daisuke and Takada, Kenta and Kamizawa, Satoshi and Tomita, Tetsuya and Sato, Eisuke and Yokota, Hiroshi},
 issue = {4},
 journal = {Journal of Medical Physics},
 month = {Dec},
 note = {Purpose: The purpose of this study is to evaluate the influence of variable relative biological effectiveness (RBE) of proton beam and dose fractionation has on dose distribution and to establish a new three-dimensional dose evaluation method for proton therapy combined with high-dose-rate (HDR) brachytherapy. Materials and Methods: To evaluate the influence of variable RBE and dose fractionation on dose distribution in proton beam therapy, the depth-dose distribution of proton therapy was compared with clinical dose, RBE-weighted dose, and equivalent dose in 2 Gy fractions using a linear-quadratic-linear model (EQD2LQL). The clinical dose was calculated by multiplying the physical dose by RBE of 1.1. The RBE-weighted dose is a biological dose that takes into account RBE variation calculated by microdosimetric kinetic model implemented in Monte Carlo code. The EQD2LQLis a biological dose that makes the RBE-weighted dose equivalent to 2 Gy using a linear-quadratic-linear (LQL) model. Finally, we evaluated the three-dimensional dose by taking into account RBE variation and LQL model for proton therapy combined with HDR brachytherapy. Results: The RBE-weighted dose increased at the distal of the spread-out Bragg peak (SOBP). With the difference in the dose fractionation taken into account, the EQD2LQLat the distal of the SOBP increased more than the RBE-weighted dose. In proton therapy combined with HDR brachytherapy, a divergence of 103% or more was observed between the conventional dose estimation method and the dose estimation method we propose. Conclusions: Our dose evaluation method can evaluate the EQD2LQLconsidering RBE changes in the dose distribution.},
 pages = {270--275},
 title = {Establishment of a new three-dimensional dose evaluation method considering variable relative biological effectiveness and dose fractionation in proton therapy combined with high-dose-rate brachytherapy},
 volume = {44},
 year = {2019},
 yomi = {イソベ, トモノリ and モリ, ユウタロウ and タケイ, ヒデユキ and クマダ, ヒロアキ and サカエ, タケジ}
}