@article{oai:tsukuba.repo.nii.ac.jp:00055294,
 author = {志鎌, あゆみ and SHIKAMA, Ayumi and Matsumoto, Harunobu and Shimokawa, Mototsugu and Nasu, Kaei and Shiozaki, Takaya and Futagami, Masayuki and Kai, Kentaro and Nagano, Hiroaki and Mori, Taisuke and Yano, Mitsutake and Sugino, Norihiro and Fujimoto, Etsuko and Yoshioka, Norihito and Nakagawa, Satoshi and Shimada, Muneaki and Tokunaga, Hideki and Yamada, Yuki and Tsuruta, Tomohiko and Tasaki, Kazuto and Nishikawa, Ryutaro and Kuji, Shiho and Motohashi, Takashi and Ito, Kimihiko and Yamada, Takashi and Teramoto, Norihiro},
 issue = {6},
 journal = {Journal of Gynecologic Oncology},
 month = {Nov},
 note = {Objective
We conducted a retrospective, multi-institutional, collaborative study to accumulate cases of neuroendocrine carcinoma of the endometrium, to clarify its clinicopathologic features, treatment, prognosis and prognostic factors to collate findings to establish future individualized treatment regimens. To our knowledge, this is the largest case study and the first study to statistically analyze the prognosis of this disease.
Methods
At medical institutions participating in the Kansai Clinical Oncology Group/Intergroup, cases diagnosed at a central pathologic review as neuroendocrine carcinoma of the endometrium between 1995 and 2014 were enrolled. We retrospectively analyzed the clinicopathologic features, treatment, prognosis and prognostic factors of this disease.
Results
A total of 65 cases were registered from 18 medical institutions in Japan. Of these, 42 (64.6%) cases were diagnosed as neuroendocrine carcinoma of the endometrium based on the central pathological review and thus included in the study. Advanced International Federation of Gynecology and Obstetrics stages (stage III and IV) and pure type small cell neuroendocrine carcinoma cases had a significantly worse prognosis. Upon multivariate analysis, only histologic subtypes and surgery were significant prognostic factors. Pure type cases had a significantly worse prognosis compared to mixed type cases and complete surgery cases had a significantly better prognosis compared to cases with no or incomplete surgery.
Conclusion
Our findings suggest that complete surgery improves the prognosis of neuroendocrine carcinoma of the endometrium. Even among cases with advanced disease stages, if complete surgery is expected to be achieved, clinicians should consider curative surgery to improve the prognosis of neuroendocrine carcinoma of the endometrium.},
 title = {Clinicopathologic features, treatment, prognosis and prognostic factors of neuroendocrine carcinoma of the endometrium: a retrospective analysis of 42 cases from the Kansai Clinical Oncology Group/Intergroup study in Japan},
 volume = {30},
 year = {2019},
 yomi = {シカマ, アユミ}
}