@article{oai:tsukuba.repo.nii.ac.jp:00055260,
 author = {星, 智也 and HOSHI, Tomoya and 佐藤, 明 and SATO, Akira and Hosoda, Hayato and Asaumi, Yasuhide and Noguchi, Teruo and Morita, Yoshiaki and Kataoka, Yu and Otsuka, Fumiyuki and Nakao, Kazuhiro and Fujino, Masashi and Nagai, Toshiyuki and Nakai, Michikazu and Nishimura, Kunihiro and Kono, Atsushi and Komori, Yoshiaki and Kawasaki, Tomohiro and Izumi, Chisato and Kusano, Kengo and Fukuda, Tetsuya and Yasuda, Satoshi},
 issue = {1},
 journal = {Journal of Cardiovascular Magnetic Resonance},
 month = {Jan},
 note = {Background
Periprocedural myocardial injury (pMI) is a common complication of elective percutaneous coronary intervention (PCI) that reduces some of the beneficial effects of coronary revascularization and impacts the risk of cardiovascular events. We developed a 3-dimensional volumetric cardiovascular magnetic resonance (CMR) method to evaluate coronary high intensity plaques and investigated their association with pMI after elective PCI.
Methods
Between October 2012 and October 2016, 141 patients with stable coronary artery disease underwent T1-weighted CMR imaging before PCI. A conventional 2-dimensional CMR plaque-to-myocardial signal intensity ratio (2D-PMR) and the newly developed 3-dimensional integral of PMR (3Di-PMR) were measured. 3Di-PMR was determined as the sum of PMRs above a threshold of > 1.0 for voxels in a target plaque. pMI was defined as high-sensitivity cardiac troponin T > 0.07 ng/mL.
Results
pMI following PCI was observed in 46 patients (33%). 3Di-PMR was significantly higher in patients with pMI than those without pMI. The optimal 3Di-PMR cutoff value for predicting pMI was 51 PMR*mm3 and the area under the receiver operating characteristic curve (0.753) was significantly greater than that for 2D-PMR (0.683, P = 0.015). 3Di-PMR was positively correlated with lipid volume (r = 0.449, P < 0.001) based on intravascular ultrasound.
Stepwise multivariable analysis showed that 3Di-PMR ≥ 51 PMR*mm3 and the presence of a side branch at the PCI target lesion site were significant predictors of pMI (odds ratio [OR], 11.9; 95% confidence interval [CI], 4.6–30.4, P < 0.001; and OR, 4.14; 95% CI, 1.6–11.1, P = 0.005, respectively).
Conclusions
3Di-PMR coronary assessment facilitates risk stratification for pMI after elective PCI.},
 title = {Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention},
 volume = {22},
 year = {2020},
 yomi = {ホシ, トモヤ and サトウ, アキラ}
}