{"created":"2021-03-01T07:35:38.871956+00:00","id":54781,"links":{},"metadata":{"_buckets":{"deposit":"4076d585-9381-4839-a2fc-e1ef35ff87ad"},"_deposit":{"id":"54781","owners":[],"pid":{"revision_id":0,"type":"depid","value":"54781"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00054781","sets":["160:4856","3:62:5296:7975"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"262","bibliographicPageStart":"257","bibliographicVolumeNumber":"9","bibliographic_titles":[{},{"bibliographic_title":"Asian Pacific Journal of Tropical Biomedicine","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To isolate, identify, and evaluate a new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth herbs.\nMethods: A dried sample of Peperomia pellucida herb was successively macerated with n-hexane and ethyl acetate. The ethyl acetate extract solution was evaporated to obtain the crude extract. Vacuum liquid column chromatography and thin layer chromatography were performed to obtain two pure compounds. Then, both compounds were elucidated and identified using the spectroscopic method. Angiotensin-converting enzyme inhibitory activity studies of both compounds were determined using angiotensin-converting enzyme kit WST-1 with spectrophotometer microplate reader 96-well at 450 nm wavelength.\nResults: Two bioactive compounds were successfully isolated from Peperomia pellucida herb, including a new compound of 2,3,5-trimethoxy-9-(12,14,15-trimethoxybenzyl)-1H-indene and pellucidin A. Both compounds demonstrated angiotensin-converting enzyme inhibitory activity, with IC50 values of 72 μM (27.95 μg/mL) and 11 μM (4.4 μg/mL), respectively.\nConclusions: In the present study, two active angiotensin-converting enzyme inhibitors were successfully isolated and purified from Peperomia pellucida which is used as an antihypertensive in traditional medicine, and support its use as an angiotensin-converting enzyme-inhibiting drug.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wolters Kluwer"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.4103/2221-1691.260398","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©2019 Asian Pacific Journal of Tropical Biomedicine Produced by Wolters Kluwer- Medknow. All rights reserved."},{"subitem_rights":"This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2221-1691","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"根岸, 紀"},{"creatorName":"ネギシ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"NEGISHI, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ahmad, Islamudin","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ambarwati, NenengSiti Silfi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Elya, Berna","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Omar, Hanita","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mulia, Kamarza","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanuar, Arry","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mun´im, Abdul","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-23"}],"displaytype":"detail","filename":"APJTB_9-6.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_10","mimetype":"application/pdf","url":{"label":"APJTB_9-6","url":"https://tsukuba.repo.nii.ac.jp/record/54781/files/APJTB_9-6.pdf"},"version_id":"af218177-3d0c-4384-8455-dea3bcf6f701"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["4856","7975"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-06-23"},"publish_date":"2020-06-23","publish_status":"0","recid":"54781","relation_version_is_last":true,"title":["A new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:29:08.211584+00:00"}