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A new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth
http://hdl.handle.net/2241/00160190
http://hdl.handle.net/2241/0016019036b037cc-2fee-488a-9617-f6f616e54e29
名前 / ファイル | ライセンス | アクション |
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APJTB_9-6 (1.4 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-06-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
根岸, 紀
× 根岸, 紀× Ahmad, Islamudin× Ambarwati, NenengSiti Silfi× Elya, Berna× Omar, Hanita× Mulia, Kamarza× Yanuar, Arry× Mun´im, Abdul |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: To isolate, identify, and evaluate a new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth herbs. Methods: A dried sample of Peperomia pellucida herb was successively macerated with n-hexane and ethyl acetate. The ethyl acetate extract solution was evaporated to obtain the crude extract. Vacuum liquid column chromatography and thin layer chromatography were performed to obtain two pure compounds. Then, both compounds were elucidated and identified using the spectroscopic method. Angiotensin-converting enzyme inhibitory activity studies of both compounds were determined using angiotensin-converting enzyme kit WST-1 with spectrophotometer microplate reader 96-well at 450 nm wavelength. Results: Two bioactive compounds were successfully isolated from Peperomia pellucida herb, including a new compound of 2,3,5-trimethoxy-9-(12,14,15-trimethoxybenzyl)-1H-indene and pellucidin A. Both compounds demonstrated angiotensin-converting enzyme inhibitory activity, with IC50 values of 72 μM (27.95 μg/mL) and 11 μM (4.4 μg/mL), respectively. Conclusions: In the present study, two active angiotensin-converting enzyme inhibitors were successfully isolated and purified from Peperomia pellucida which is used as an antihypertensive in traditional medicine, and support its use as an angiotensin-converting enzyme-inhibiting drug. |
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書誌情報 |
en : Asian Pacific Journal of Tropical Biomedicine 巻 9, 号 6, p. 257-262, 発行日 2019-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2221-1691 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.4103/2221-1691.260398 | |||||
権利 | ||||||
権利情報 | ©2019 Asian Pacific Journal of Tropical Biomedicine Produced by Wolters Kluwer- Medknow. All rights reserved. | |||||
権利 | ||||||
権利情報 | This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Wolters Kluwer |