WEKO3
アイテム
{"_buckets": {"deposit": "7b11ac09-78ea-4a5a-a639-6c95b9ae53c1"}, "_deposit": {"id": "54767", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "54767"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00054767", "sets": ["7352", "2196", "7967"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageStart": "918", "bibliographicVolumeNumber": "8", "bibliographic_titles": [{}, {"bibliographic_title": "Cells", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Photodynamic therapy (PDT) is a cancer treatment involving the generation of reactive oxygen species (ROS) by laser irradiation of porphyrins that accumulate in cancer tissues. 5-aminolevulinic acid (ALA), a porphyrin precursor, is often used as a photosensitizer. ALA is imported into cells via peptide transporter 1 (PEPT1), and porphyrin is exported via ATP-binding cassette member 2 of subfamily G (ABCG2). Thus, cancer cell-specific porphyrin accumulation involves regulation of both transporters to enhance the ALA-PDT effect. We reported previously that mitochondrial ROS (mitROS) upregulated PEPT1 expression and downregulated ABCG2 expression. Therefore, we propose that increasing mitROS production will enhance ALA-PDT cytotoxicity. Cisplatin is a chemotherapeutic drug that induces intracellular ROS generation. In this study, we investigated whether cisplatin-increased mitROS production in gastric cancer cell lines (RGK36 and RGK45) enhanced the cytotoxicity of ALA-PDT by regulation the expression of both PEPT1 and ABCG2. The results showed that cisplatin increased intracellular mitROS production in cancer but not normal cells (RGM1). PEPT1 was upregulated and ABCG2 downregulated in cancer cells treated with cisplatin. Moreover, intracellular porphyrin accumulation and ALA-PDT cytotoxicity increased. We conclude that cisplatin treatment increases the intracellular mitROS concentration and upregulates PEPT1 and downregulates ABCG2 expression.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": " 31426474", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3390/cells8080918", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2019 by the authors."}, {"subitem_rights": "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2073-4409", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "黒川, 宏美"}, {"creatorName": "クロカワ, ヒロミ", "creatorNameLang": "ja-Kana"}, {"creatorName": "KUROKAWA, Hiromi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "204255", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30791496", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000030791496"}, {"nameIdentifier": "0000004183", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000004183"}]}, {"creatorNames": [{"creatorName": "松井, 裕史"}, {"creatorName": "マツイ, ヒロフミ", "creatorNameLang": "ja-Kana"}, {"creatorName": "MATSUI, Hirofumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106737", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70272200", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000070272200"}, {"nameIdentifier": "0000001752", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001752"}]}, {"creatorNames": [{"creatorName": "Ito, Hiromu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "219737", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Cells_8-8.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "Cells_8-8", "url": "https://tsukuba.repo.nii.ac.jp/record/54767/files/Cells_8-8.pdf"}, "version_id": "ad0a6d7f-e10a-4b63-99b1-90397c08f63f"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Cisplatin-Derived Increase of Mitochondrial Reactive Oxygen Species Enhances the Effectiveness of Photodynamic Therapy via Transporter Regulation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Cisplatin-Derived Increase of Mitochondrial Reactive Oxygen Species Enhances the Effectiveness of Photodynamic Therapy via Transporter Regulation", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["7352", "2196", "7967"], "permalink_uri": "http://hdl.handle.net/2241/00160176", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-06-19"}, "publish_date": "2020-06-19", "publish_status": "0", "recid": "54767", "relation": {}, "relation_version_is_last": true, "title": ["The Cisplatin-Derived Increase of Mitochondrial Reactive Oxygen Species Enhances the Effectiveness of Photodynamic Therapy via Transporter Regulation"], "weko_shared_id": 5}
The Cisplatin-Derived Increase of Mitochondrial Reactive Oxygen Species Enhances the Effectiveness of Photodynamic Therapy via Transporter Regulation
http://hdl.handle.net/2241/00160176
http://hdl.handle.net/2241/001601763b981264-1608-4175-b186-7d12c234da17
名前 / ファイル | ライセンス | アクション |
---|---|---|
Cells_8-8 (1.1 MB)
|
Item type | Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-06-19 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Cisplatin-Derived Increase of Mitochondrial Reactive Oxygen Species Enhances the Effectiveness of Photodynamic Therapy via Transporter Regulation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
黒川, 宏美
× 黒川, 宏美× 松井, 裕史× Ito, Hiromu |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Photodynamic therapy (PDT) is a cancer treatment involving the generation of reactive oxygen species (ROS) by laser irradiation of porphyrins that accumulate in cancer tissues. 5-aminolevulinic acid (ALA), a porphyrin precursor, is often used as a photosensitizer. ALA is imported into cells via peptide transporter 1 (PEPT1), and porphyrin is exported via ATP-binding cassette member 2 of subfamily G (ABCG2). Thus, cancer cell-specific porphyrin accumulation involves regulation of both transporters to enhance the ALA-PDT effect. We reported previously that mitochondrial ROS (mitROS) upregulated PEPT1 expression and downregulated ABCG2 expression. Therefore, we propose that increasing mitROS production will enhance ALA-PDT cytotoxicity. Cisplatin is a chemotherapeutic drug that induces intracellular ROS generation. In this study, we investigated whether cisplatin-increased mitROS production in gastric cancer cell lines (RGK36 and RGK45) enhanced the cytotoxicity of ALA-PDT by regulation the expression of both PEPT1 and ABCG2. The results showed that cisplatin increased intracellular mitROS production in cancer but not normal cells (RGM1). PEPT1 was upregulated and ABCG2 downregulated in cancer cells treated with cisplatin. Moreover, intracellular porphyrin accumulation and ALA-PDT cytotoxicity increased. We conclude that cisplatin treatment increases the intracellular mitROS concentration and upregulates PEPT1 and downregulates ABCG2 expression. | |||||
書誌情報 |
en : Cells 巻 8, 号 8, p. 918, 発行日 2019-08 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2073-4409 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 31426474 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/cells8080918 | |||||
権利 | ||||||
権利情報 | © 2019 by the authors. | |||||
権利 | ||||||
権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | MDPI |