{"created":"2021-03-01T07:35:08.890377+00:00","id":54331,"links":{},"metadata":{"_buckets":{"deposit":"ea44608c-def7-411c-9a75-c2c60693989e"},"_deposit":{"id":"54331","owners":[],"pid":{"revision_id":0,"type":"depid","value":"54331"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00054331","sets":["117:7598","3:62:5298:5460"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1029","bibliographicPageStart":"1023","bibliographicVolumeNumber":"67","bibliographic_titles":[{},{"bibliographic_title":"Chemical & pharmaceutical bulletin","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The combinatorial synthesis and biological evaluation of destruxins are described herein. First, the total synthesis of destruxin E was achieved, and its absolute configuration was successfully determined to be (S). In addition, the preparation of a combinatorial library based on the structure of destruxins was carried out by the split-and-pool method. Biological evaluation of the resulting analogs against osteoclast-like multinuclear cells (OCLs) revealed that the N-methyl-alanine residue was crucial to inducing morphological changes in OCLs. In particular, functionalization at the β-position of the proline (Pro) residue was found to be tolerant of the desired biological activity of destruxin E, suggesting that the β-position of the Pro residue should be a promising site for the introduction of a chemical tag toward the preparation of a molecular probe.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan"}]},"item_5_publisher_28":{"attribute_name":"出版者別名","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31582623","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/cpb.c19-00272","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 The Pharmaceutical Society of Japan"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 将人"},{"creatorName":"ヨシダ, マサヒト","creatorNameLang":"ja-Kana"},{"creatorName":"YOSHIDA, Masahito","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-17"}],"displaytype":"detail","filename":"CPB_67-10.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CPB_67-10","url":"https://tsukuba.repo.nii.ac.jp/record/54331/files/CPB_67-10.pdf"},"version_id":"6e3d32c1-178e-4d27-afa2-64dfd53afd52"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Combinatorial Synthesis and Biological Evaluation of Destruxins","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Combinatorial Synthesis and Biological Evaluation of Destruxins","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["7598","5460"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-17"},"publish_date":"2020-03-17","publish_status":"0","recid":"54331","relation_version_is_last":true,"title":["Combinatorial Synthesis and Biological Evaluation of Destruxins"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:28:40.070950+00:00"}