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Classic Hodgkin Lymphoproliferative Diseases Clonally Unrelated to B-Chronic Lymphocytic Leukemia Successfully Treated with Bendamustine Plus Rituximab
http://hdl.handle.net/2241/00159487
http://hdl.handle.net/2241/001594877422b01e-d393-430d-82b1-6fc9c4b8b300
名前 / ファイル | ライセンス | アクション |
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Cancers_10-9 (1.6 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-01-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Classic Hodgkin Lymphoproliferative Diseases Clonally Unrelated to B-Chronic Lymphocytic Leukemia Successfully Treated with Bendamustine Plus Rituximab | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
松岡, 亮太
× 松岡, 亮太× Rai, Shinya× Tanaka, Hirokazu× Fujimoto, Ko× Kumode, Takahiro× Inoue, Hiroaki× Taniguchi, Yasuhiro× Morita, Yasuyoshi× Espinoza, J. Luis× Tatsumi, Yoichi× Ashida, Takashi× Kikuti, Yukie Yara× Nakamura, Naoya× Matsumura, Itaru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A 62-year-old male was diagnosed with chronic lymphocytic leukemia (CLL) and treated with a fludarabine-containing regimen which maintained the disease in a partial response. Nine years after diagnosis, a rapidly growing systemic lymphadenopathy was observed, and a biopsy specimen revealed the presence of typical Hodgkin/Reed-Sternberg (HRS) cells, surrounded by T-lymphocytes and CLL cells. Sequencing analysis of the germline complementary determining region 3 (CDR3) region of the immunoglobulin heavy chain (IGH) gene showed that the Hodgkin/Reed-Sternberg cells were clonally unrelated to the preexisting CLL cells and the HRS cells were composed of five different clones, leading to the molecular diagnosis of de novo lymphocyte-rich classic Hodgkin lymphoproliferative diseases (LPDs) with small lymphocytic lymphoma (SLL). As the initial treatment was neither effective for classic Hodgkin LPDs nor for SLL, Bendamustine, Rituximab (BR) was started and complete remission was achieved, which has continued for more than one year so far. BR may be a good therapeutic option for both entities without causing hematological toxicity. | |||||
書誌情報 |
en : Cancers 巻 10, 号 9, p. 304, 発行日 2018-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2072-6694 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30177612 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/cancers10090304 | |||||
権利 | ||||||
権利情報 | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | MDPI |