{"created":"2021-03-01T07:34:36.975047+00:00","id":53870,"links":{},"metadata":{"_buckets":{"deposit":"567c44e8-dd11-4bab-a195-d1f514b17021"},"_deposit":{"id":"53870","owners":[],"pid":{"revision_id":0,"type":"depid","value":"53870"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00053870","sets":["2780:1281","2780:1759","2780:3023","2780:3353","2780:5104","2780:5550","2780:7803","2780:970","3:62:5298:7336"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"620","bibliographicPageStart":"613","bibliographicVolumeNumber":"12","bibliographic_titles":[{},{"bibliographic_title":"Case Reports in Oncology","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Small-cell lung cancer (SCLC) is highly sensitive to platinum-based chemotherapy. However, its indication in patients with a poor performance status (PS) at initial diagnosis is controversial. We retrospectively reviewed all clinical courses of pathologically diagnosed SCLC patients with poor PS, Eastern Cooperative Oncology Group PS 3 and 4. Among 18 patients, 12 were treated with chemotherapy and 6 with supportive care alone. During the chemotherapy courses, PS improved in 7 (58.3%, including the PS 4 cases), remained stable in 2 (16.7%), and deteriorated in 3 (25%) patients. Moreover, 5 patients showed partial responses to chemotherapy (response rate of 41.7%). Grade 3-4 neutropenia developed in 10 (83.3%) patients and grade 3 febrile neutropenia occurred in 5 (41.7%) patients, but no grade 4 non-hematological toxicity was noted. Mortality associated with lung toxicity (grade 5) due to treatment occurred in a 77-year-old-male patient with PS 3. No substantial difference in survival was observed between patients with PS 3 and 4, even when including those treated with supportive care alone. Treatment had a positive effect on survival: after chemotherapy, the 6-month survival rate of PS 3 and 4 patients was 66.7%. In contrast, all patients treated with supportive care alone died within 5 months. These findings suggest that chemotherapy is indicated in selected SCLC patients not only with PS 3, but also with PS 4. (C) 2019 The Author(s) Published by S. Karger AG, Basel","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Karger"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31543777","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1159/000501548","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s) Published by S. Karger AG, Basel www.karger.com/cro This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1662-6575","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12780955","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中澤, 健介"},{"creatorName":"ナカザワ, ケンスケ","creatorNameLang":"ja-Kana"},{"creatorName":"NAKAZAWA, Kensuke","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"塩澤, 利博"},{"creatorName":"シオザワ, トシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"SHIOZAWA , Toshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小川, 良子"},{"creatorName":"オガワ, リョウコ","creatorNameLang":"ja-Kana"},{"creatorName":"OGAWA, Ryoko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"際本, 拓未"},{"creatorName":"キワモト, タクミ","creatorNameLang":"ja-Kana"},{"creatorName":"KIWAMOTO, Takumi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"森島, 祐子"},{"creatorName":"モリシマ, ユウコ","creatorNameLang":"ja-Kana"},{"creatorName":"MORISHIMA, Yuko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"坂本, 透"},{"creatorName":"サカモト, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"SAKAMOTO, Tohru","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"関根, 郁夫"},{"creatorName":"セキネ, イクオ","creatorNameLang":"ja-Kana"},{"creatorName":"SEKINE, Ikuo","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"檜澤, 伸之"},{"creatorName":"ヒザワ, ノブユキ","creatorNameLang":"ja-Kana"},{"creatorName":"HIZAWA, Nobuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Aida, Yuka","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-14"}],"displaytype":"detail","filename":"CRO_12-2.pdf","filesize":[{"value":"365.5 kB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"CRO_12-2","url":"https://tsukuba.repo.nii.ac.jp/record/53870/files/CRO_12-2.pdf"},"version_id":"41ca7e6b-2603-4fc5-864e-031b3d68b756"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Small-Cell Lung Cancer Treatment of Newly Diagnosed Patients with Poor Performance Status","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Small-Cell Lung Cancer Treatment of Newly Diagnosed Patients with Poor Performance Status","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["3023","5550","1759","7803","5104","3353","970","1281","7336"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-14"},"publish_date":"2020-01-14","publish_status":"0","recid":"53870","relation_version_is_last":true,"title":["Small-Cell Lung Cancer Treatment of Newly Diagnosed Patients with Poor Performance Status"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:27:56.522511+00:00"}