@article{oai:tsukuba.repo.nii.ac.jp:00053870,
 author = {中澤, 健介 and NAKAZAWA, Kensuke and 塩澤, 利博 and SHIOZAWA , Toshihiro and 小川, 良子 and OGAWA, Ryoko and 際本, 拓未 and KIWAMOTO, Takumi and 森島, 祐子 and MORISHIMA, Yuko and 坂本, 透 and SAKAMOTO, Tohru and 関根, 郁夫 and SEKINE, Ikuo and 檜澤, 伸之 and HIZAWA, Nobuyuki and Aida, Yuka},
 issue = {2},
 journal = {Case Reports in Oncology},
 month = {Aug},
 note = {Small-cell lung cancer (SCLC) is highly sensitive to platinum-based chemotherapy. However, its indication in patients with a poor performance status (PS) at initial diagnosis is controversial. We retrospectively reviewed all clinical courses of pathologically diagnosed SCLC patients with poor PS, Eastern Cooperative Oncology Group PS 3 and 4. Among 18 patients, 12 were treated with chemotherapy and 6 with supportive care alone. During the chemotherapy courses, PS improved in 7 (58.3%, including the PS 4 cases), remained stable in 2 (16.7%), and deteriorated in 3 (25%) patients. Moreover, 5 patients showed partial responses to chemotherapy (response rate of 41.7%). Grade 3-4 neutropenia developed in 10 (83.3%) patients and grade 3 febrile neutropenia occurred in 5 (41.7%) patients, but no grade 4 non-hematological toxicity was noted. Mortality associated with lung toxicity (grade 5) due to treatment occurred in a 77-year-old-male patient with PS 3. No substantial difference in survival was observed between patients with PS 3 and 4, even when including those treated with supportive care alone. Treatment had a positive effect on survival: after chemotherapy, the 6-month survival rate of PS 3 and 4 patients was 66.7%. In contrast, all patients treated with supportive care alone died within 5 months. These findings suggest that chemotherapy is indicated in selected SCLC patients not only with PS 3, but also with PS 4. (C) 2019 The Author(s) Published by S. Karger AG, Basel},
 pages = {613--620},
 title = {Small-Cell Lung Cancer Treatment of Newly Diagnosed Patients with Poor Performance Status},
 volume = {12},
 year = {2019},
 yomi = {ナカザワ, ケンスケ and シオザワ, トシヒロ and オガワ, リョウコ and キワモト, タクミ and モリシマ, ユウコ and サカモト, トオル and セキネ, イクオ and ヒザワ, ノブユキ}
}