{"created":"2021-03-01T07:33:04.500616+00:00","id":52498,"links":{},"metadata":{"_buckets":{"deposit":"afd5a27c-5b7c-4c08-876a-ad9bbbc2d1ef"},"_deposit":{"id":"52498","owners":[],"pid":{"revision_id":0,"type":"depid","value":"52498"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00052498","sets":["2780:938","3:62:5616:7691"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"266","bibliographicPageStart":"261","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"耳鼻咽喉科免疫アレルギー"},{"bibliographic_title":"Journal of Japan Society of Immunology & Allergology in Otolaryngology","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"好酸球性副鼻腔炎（ECRS）は，鼻腔内に多発性鼻茸を有し，鼻茸・末梢血中に好酸球増加を伴う難治性副鼻腔炎である。次世代シーケンサーを用いた，鼻茸のRNA-sequencingにおけるtranscriptome解析では，ECRS患者の鼻茸でCST1の発現が高い傾向にあった。我々はCST1がECRSの病態に関与していると考え，ECRSの鼻茸内でのCST1の発現や働きについて詳細な検討を行った。CRSwNP患者の鼻茸内におけるCST1の発現に関して，real-time PCRを用いたmRNAの発現・免疫組織化学を用いた解析では，non-ECRS患者群に比べて，ECRS患者群でCST1が有意に高発現していた。特にCST1はsevere ECRSの鼻茸上皮で強い発現を示していた。つまり，CST1の発現は，ECRSの難治性や再発性と関連する。ECRS由来の鼻茸上皮細胞を精製し，IL-4+dsRNA+CST1で刺激すると，IL-4+dsRNAで刺激した時に比べて，TSLPの発現が有意に上昇した。鼻茸上皮細胞へのTSLPあるいはIL-33の刺激は，CST1の発現を誘導した。また，ECRS由来の鼻茸線維芽細胞に対するCST1の刺激は，CCL11とperiostinの発現を誘導した。CST1は鼻茸内において，ECRSの鼻茸形成・増悪に関わる様々な因子と相互作用することにより，Th2/好酸球性炎症として作用し，鼻茸の重症化，難治性，再発に関わる。ECRSの鼻茸に対して，CST1をtargetとした治療戦略が有用となる可能性がある。本稿では，CST1のECRSにおける役割を中心に解説する。","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本耳鼻咽喉科免疫アレルギー学会"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.5648/jjiao.36.261","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©2018 Japan Society of Immunology & Allergology in Otolaryngology"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0913-0691","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00139176","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野口, 惠美子"},{"creatorName":"ノグチ, エミコ","creatorNameLang":"ja-Kana"},{"creatorName":"NOGUCHI, Emiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kato, Yukinori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takabayashi, Tetsuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakashita, Masafumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imoto, Yoshimasa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokunaga, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ninomiya, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morikawa, Taiyo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Kanako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujieda, Shigeharu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-23"}],"displaytype":"detail","filename":"耳鼻咽喉科36-4-261.pdf","filesize":[{"value":"3.0 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polyps","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["938","7691"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-10-23"},"publish_date":"2019-10-23","publish_status":"0","recid":"52498","relation_version_is_last":true,"title":["好酸球性副鼻腔炎におけるCST1の発現と機能的解析"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:26:04.078921+00:00"}