@article{oai:tsukuba.repo.nii.ac.jp:00052175,
 author = {松坂, 賢 and MATSUZAKA, Takashi and 矢藤, 繁 and YATOH, Shigeru and 鈴木, 浩明 and SUZUKI, Hiroaki and 會田, 雄一 and AITA, Yuichi and 矢作, 直也 and YAHAGI, Naoya and 宮本, 崇史 and MIYAMOTO, Takafumi and 中川, 嘉 and NAKAGAWA, Yoshimi and 島野, 仁 and SHIMANO, Hitoshi and Sharma, Rahul and Kaushik, Mahesh K. and Sugasawa, Takehito and Ohno, Hiroshi and Wang, Yunong and Motomura, Kaori and Shimura, Takuya and Okajima, Yuka and Mizunoe, Yuhei and Ma, Yang and Saber, Zahara M. and Iwasaki, Hitoshi and Han, Song-iee and Takeuchi, Yoshinori and Sekiya, Motohiro},
 journal = {Scientific Reports},
 month = {Mar},
 note = {Brown adipose tissue (BAT) is an attractive therapeutic target for treating obesity and metabolic diseases. Octacosanol is the main component of policosanol, a mixture of very long chain aliphatic alcohols obtained from plants. The current study aimed to investigate the effect of octacosanol and policosanol on high-fat diet (HFD)-induced obesity. Mice were fed on chow, or HFD, with or without octacosanol or policosanol treatment for four weeks. HFD-fed mice showed significantly higher body weight and body fat compared with chow-fed mice. However, mice fed on HFD treated with octacosanol or policosanol (HFDo/p) showed lower body weight gain, body fat gain, insulin resistance and hepatic lipid content. Lower body fat gain after octacosanol or policosanol was associated with increased BAT activity, reduced expression of genes involved in lipogenesis and cholesterol uptake in the liver, and amelioration of white adipose tissue (WAT) inflammation. Moreover, octacosanol and policosanol significantly increased the expression of Ffar4, a gene encoding polyunsaturated fatty acid receptor, which activates BAT thermogenesis. Together, these results suggest that octacosanol and policosanol ameliorate diet-induced obesity and metabolic disorders by increasing BAT activity and improving hepatic lipid metabolism. Thus, these lipids represent promising therapeutic targets for the prevention and treatment of obesity and obesity-related metabolic disorders.},
 title = {Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism},
 volume = {9},
 year = {2019},
 yomi = {マツザカ, タカシ and ヤトウ, シゲル and スズキ, ヒロアキ and アイタ, ユウイチ and ヤハギ, ナオヤ and ミヤモト, タカフミ and ナカガワ, ヨシミ and シマノ, ヒトシ}
}