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Killed Bifidobacterium longum enhanced stress tolerance and prolonged life span of Caenorhabditis elegans via DAF-16
http://hdl.handle.net/2241/00157149
http://hdl.handle.net/2241/0015714944862373-61c3-453e-96aa-04f68625818b
名前 / ファイル | ライセンス | アクション |
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BJN_120 (4.8 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-07-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Killed Bifidobacterium longum enhanced stress tolerance and prolonged life span of Caenorhabditis elegans via DAF-16 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
坂本, 和一
× 坂本, 和一× Sugawara, Takaya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Probiotics are bacteria among the intestinal flora that are beneficial for human health. Bifidobacterium longum (BL) is a prototypical probiotic that is widely used in yogurt making, supplements and others. Although various physiological effects of BL have been reported, those associated with longevity and anti-ageing still remain elusive. Here we aimed to elucidate the physiological effects of killed BL (BR-108) on stress tolerance and longevity of Caenorhabditis elegans and their mechanisms. Worms fed killed BL in addition to Escherichia coli (OP50) displayed reduced body length in a BL dose-dependent manner. When compared with those fed E. coli alone, these worms had a higher survival rate following heat stress at 35°C and hydrogen peroxide-induced oxidative stress. A general decrease in motility was observed over time in all worms; however, killed BL-fed ageing worms displayed increased movement and longer life span than those fed E. coli alone. However, the longevity effect was suppressed in sir-2.1, daf-16 and skn-1-deficient worms. Killed BL induced DAF-16 nuclear localisation and increased the expression of the DAF-16 target gene hsp-12.6. These results revealed that the physiological effects of killed BL in C. elegans were mediated by DAF-16 activation. These findings contradict previous observations with different Bifidobacterium and Lactobacillus strains, which showed the role for SKN-1 independently of DAF-16. | |||||
書誌情報 |
en : British Journal of Nutrition 巻 120, 号 8, p. 872-880, 発行日 2018-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0007-1145 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00574708 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30178731 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1017/S0007114518001563 | |||||
権利 | ||||||
権利情報 | © The Authors 2018 | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Cambridge University Press |