@article{oai:tsukuba.repo.nii.ac.jp:00049597,
 author = {山岸, 良匡 and YAMAGISHI, Kazumasa and 山海, 知子 and SANKAI, Tomoko and Ikeda, Ai and Chei, Choy-Lye and Noda, Hiroyuki and Umesawa, Mitsumasa and Cui, Renzhe and Muraki, Isao and Ohira, Tetsuya and Imano, Hironori and Okada, Takeo and Tanigawa, Takeshi and Kitamura, Akihiko and Kiyama, Masahiko and Iso, Hiroyasu},
 issue = {3},
 journal = {Clinical nutrition},
 month = {Jun},
 note = {Background & aims
It has been hypothesized that ω-3 polyunsaturated fatty acids have anti-atherosclerotic and neuronal protective functions and may benefit prevention of dementia, but the epidemiological evidence, especially for α-linolenic acid, is quite limited. The aim of this study was to examine whether serum ω-3 polyunsaturated fatty acids are associated with risk of dementia.
Methods
We performed an intracohort case–control study nested in a community-based cohort, the Circulatory Risk in Communities Study, involving 7586 Japanese individuals aged 40–74 years at the baseline period of 1984–1994. Omega-3 polyunsaturated fatty acid constituents (α-linolenic, eicosapentaenoic, and docosahexaenoic acids) in serum total lipid were measured in 315 cases of incident disabling dementia in the above-mentioned cohort between 1999 and 2004, and in 630 controls whose age, sex, area, and baseline year were matched with the cases.
Results
As we had postulated, serum α-linolenic acid was inversely associated with risk of disabling dementia: the multivariate odds ratios (95% confidence intervals) were 0.57 (0.39–0.85), 0.51 (0.34–0.76), and 0.61 (0.41–0.90) for persons with the second, third, and highest quartiles of serum α-linolenic acid, respectively, as compared with the lowest quartile (P for trend = 0.01). Associations of other ω-3 fatty acids with disabling dementia were not statistically significant.
Conclusions
Serum α-linolenic acid was inversely associated with risk of disabling dementia. Although the causality needs to be confirmed by randomized control trials, we identified serum α-linolenic acid as a biomarker that predicts future dementia.},
 pages = {793--797},
 title = {Serum α-linolenic and other ω-3 fatty acids, and risk of disabling dementia: Community-based nested case–control study},
 volume = {36},
 year = {2017},
 yomi = {ヤマギシ, カズマサ and サンカイ, トモコ}
}