{"created":"2021-03-01T07:29:31.590099+00:00","id":49327,"links":{},"metadata":{"_buckets":{"deposit":"9c40c315-2bf1-491f-bdbb-d30165bb9763"},"_deposit":{"id":"49327","owners":[],"pid":{"revision_id":0,"type":"depid","value":"49327"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00049327","sets":["2780:2179","2780:2607","2780:5106","2780:5274","2780:5276","2780:5695","3:62:5598:7294"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"45","bibliographicPageStart":"41","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Papillomavirus Research"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The prognostic impact of human papillomavirus (HPV) type on invasive cervical cancer (ICC) was analyzed for 137 women treated for ICC at a single institution between 1999 and 2007. The study subjects were divided into three groups according to HPV genotype: HPV16-positive (n = 59), HPV18-positive (n = 33), and HPV16/18-negative ICC (non-HPV16/18, n = 45). The median follow-up time was 102.5 months (range, 5–179). The 10-year overall survival (10y-OS) rates in women with FIGO stage I/II disease were similar among HPV genotypes: 94.7% for HPV16 (n = 39), 95.2% for HPV18 (n = 26), and 96.4% for non-HPV16/18 (n = 29). However, the 10y-OS rates in women with FIGO stage III/IV tumors were 73.7% for HPV16 (n = 20), 45.7% for HPV18 (n = 7), and 35.7% for other types (n = 16), with significantly higher survival in HPV16-positive compared with HPV16-negative ICC (10y-OS; 73.7% vs. 39.5%, P = 0.04). This difference in FIGO stage III/IV tumors remained significant after adjusting for age and histology (hazard ratio 0.30, 95% confidence interval 0.09–0.86, P = 0.02). These results suggest that detection of HPV16 DNA may be associated with a favorable prognosis in patients with FIGO stage III/IV ICC. Given that most women with FIGO stage III/IV tumors received concurrent chemoradiotherapy, this finding may imply that HPV16-positive tumors are more chemoradiosensitive.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30347290","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.pvr.2018.10.005","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"24058521","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"秋山, 梓"},{"creatorName":"アキヤマ, アズサ","creatorNameLang":"ja-Kana"},{"creatorName":"AKIYAMA, Azusa","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"櫻井, 学"},{"creatorName":"サクライ, マナブ","creatorNameLang":"ja-Kana"},{"creatorName":"SAKURAI, Manabu","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"水口, 剛雄"},{"creatorName":"ミナグチ, タケオ","creatorNameLang":"ja-Kana"},{"creatorName":"MINAGUCHI, Takeo","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"沖, 明典"},{"creatorName":"オキ, アキノリ","creatorNameLang":"ja-Kana"},{"creatorName":"OKI, Akinori","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"佐藤, 豊実"},{"creatorName":"サトウ, トヨミ","creatorNameLang":"ja-Kana"},{"creatorName":"SATOH, Toyomi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"吉川, 裕之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onuki, Mamiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tenjimbayashi, Yuri","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tasaka, Nobutaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshikawa, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-07"}],"displaytype":"detail","filename":"PR_6-41.pdf","filesize":[{"value":"405.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PR_6-41","url":"https://tsukuba.repo.nii.ac.jp/record/49327/files/PR_6-41.pdf"},"version_id":"2f823a5e-d28b-4d2e-954f-8f6a41f4f1c8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Human papillomavirus genotype and prognosis of cervical cancer: Favorable survival of patients with HPV16-positive tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human papillomavirus genotype and prognosis of cervical cancer: Favorable survival of patients with HPV16-positive tumors"}]},"item_type_id":"5","owner":"1","path":["5695","5106","5274","2179","5276","2607","7294"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-07"},"publish_date":"2019-03-07","publish_status":"0","recid":"49327","relation_version_is_last":true,"title":["Human papillomavirus genotype and prognosis of cervical cancer: Favorable survival of patients with HPV16-positive tumors"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:21:52.288368+00:00"}