{"created":"2021-03-01T07:28:16.209364+00:00","id":48199,"links":{},"metadata":{"_buckets":{"deposit":"816ce0e8-3bc7-4b01-8a55-4b34eb6d2f88"},"_deposit":{"id":"48199","owners":[],"pid":{"revision_id":0,"type":"depid","value":"48199"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00048199","sets":["3:62:5591:606","7131:543","7131:988"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"434","bibliographicPageStart":"429","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"International immunology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田原, 聡子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"渋谷, 彰"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although airway hyperresponsiveness (AHR) is a prominent feature of asthma, how it is regulated remains incompletely understood. Allergin-1, an inhibitory immunoglobulin-like receptor containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), is expressed on human and mouse mast cells (MCs) and inhibits high-affinity receptor for IgE (FcεRI)-mediated signaling. Using MC-deficient KitW-sh/W-sh mice and Mas-TRECK mice, which carries a diphtheria toxin (DT)-induced MC deletion system based on il4 enhancer elements, we demonstrate here that MCs are involved in the induction of house dust mite (HDM)-induced AHR. Further, we show that MCs deficient in Allergin-1 exacerbated HDM-induced AHR, but had no effect on airway inflammation. In vitro analysis demonstrated that Allergin-1 inhibited anti-HDM allergen antibody-dependent HDM allergen-mediated degranulation by MCs. Thus, Allergin-1 on MCs plays an important role in the regulation of HDM-induced AHR.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30169732","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/intimm/dxy025","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©  The Japanese Society for Immunology. 2018."},{"subitem_rights":"This is a pre-copyedited, author-produced version of an article accepted for publication in International Immunology following peer review. The version of record International Immunology, Volume 30, Issue 9, 30 August 2018, Pages 429–434 is available online at: https://doi.org/10.1093/intimm/dxy025."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0953-8178","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10730708","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hitomi, Kaori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tahara-Hanaoka, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miki, Haruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwata, Kanako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibayama, Shiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibuya, Akira"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-01"}],"displaytype":"detail","filename":"InterImmu_30-9.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"InterImmu_30-9","url":"https://tsukuba.repo.nii.ac.jp/record/48199/files/InterImmu_30-9.pdf"},"version_id":"db9feb9c-8c65-4caf-9bcf-295c9869d59e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice"}]},"item_type_id":"5","owner":"1","path":["543","988","606"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-15"},"publish_date":"2018-11-15","publish_status":"0","recid":"48199","relation_version_is_last":true,"title":["Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:20:22.465942+00:00"}