@article{oai:tsukuba.repo.nii.ac.jp:00048199,
 author = {田原, 聡子 and 渋谷, 彰 and Hitomi, Kaori and Tahara-Hanaoka, Satoko and Miki, Haruka and Iwata, Kanako and Shibayama, Shiro and Kubo, Masato and Shibuya, Akira},
 issue = {9},
 journal = {International immunology},
 month = {Aug},
 note = {Although airway hyperresponsiveness (AHR) is a prominent feature of asthma, how it is regulated remains incompletely understood. Allergin-1, an inhibitory immunoglobulin-like receptor containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), is expressed on human and mouse mast cells (MCs) and inhibits high-affinity receptor for IgE (FcεRI)-mediated signaling. Using MC-deficient KitW-sh/W-sh mice and Mas-TRECK mice, which carries a diphtheria toxin (DT)-induced MC deletion system based on il4 enhancer elements, we demonstrate here that MCs are involved in the induction of house dust mite (HDM)-induced AHR. Further, we show that MCs deficient in Allergin-1 exacerbated HDM-induced AHR, but had no effect on airway inflammation. In vitro analysis demonstrated that Allergin-1 inhibited anti-HDM allergen antibody-dependent HDM allergen-mediated degranulation by MCs. Thus, Allergin-1 on MCs plays an important role in the regulation of HDM-induced AHR.},
 pages = {429--434},
 title = {Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice},
 volume = {30},
 year = {2018}
}